P22608

PR
Gene name
pilB (PA4526)
Protein name
Type IV pilus assembly ATPase PilB
Names
Species
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG Pathway
pae:PA4526
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-69 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P22608

Entry ID Method Resolution Chain Position Source
AF-P22608-F1 Predicted AlphaFoldDB

11 variants for P22608

Variant ID(s) Position Change Description Diseaes Association Provenance
26 V>L strain: PAK [UniProt] No
30 A>T strain: PAK [UniProt] No
46 S>N strain: PAK [UniProt] No
74 K>R strain: PAK [UniProt] No
109 P>A strain: PAK [UniProt] No
146 S>N strain: PAK [UniProt] No
164 I>VGVKETSG strain: PAK [UniProt] No
175 A>TG strain: PAK [UniProt] No
467 E>D strain: PAK [UniProt] No
470 R>K strain: PAK [UniProt] No
481 D>EL strain: PAK [UniProt] No

No associated diseases with P22608

4 regional properties for P22608

Type Name Position InterPro Accession
domain Cryptochrome/DNA photolyase, FAD-binding domain 241 - 395 IPR005101
domain DNA photolyase, N-terminal 2 - 153 IPR006050
conserved_site Cryptochrome/DNA photolyase class 1, conserved site, C-terminal 290 - 302 IPR018394-1
conserved_site Cryptochrome/DNA photolyase class 1, conserved site, C-terminal 310 - 329 IPR018394-2

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Displays polar localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
metal ion binding Binding to a metal ion.

4 GO annotations of biological process

Name Definition
cell motility Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
type IV pilus assembly The assembly from its constituent parts of a type IV pilus.
type IV pilus-dependent motility Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNDSIQLSGL SRQLVQANLL DEKTAVQAQA QAQRNKLSLV THLVQSKLVS GLALAELSAE
70 80 90 100 110 120
QFGIAYCDLN SLDKESFPRD AISEKLVRQH RVIPLWRRGN KLFVGISDPA NHQAINDVQF
130 140 150 160 170 180
STGLTTEAIL VEDDKLGLAI DKLFESATDG LAGLDDVDLE GLDIGSADKS TQEDASAEAD
190 200 210 220 230 240
DAPVVRFVNK MLLDAIKGGS SDLHFEPYEK IYRVRFRTDG MLHEVAKPPI QLASRISARL
250 260 270 280 290 300
KVMAGLDISE RRKPQDGRIK MRVSKTKSID FRVNTLPTLW GEKIVMRILD SSSAQMGIDA
310 320 330 340 350 360
LGYEEDQKEL YLAALKQPQG MILVTGPTGS GKTVSLYTGL NILNTTDINI STAEDPVEIN
370 380 390 400 410 420
LEGINQVNVN PRQGMDFSQA LRAFLRQDPD VIMVGEIRDL ETAEIAIKAA QTGHMVMSTL
430 440 450 460 470 480
HTNSAAETLT RLLNMGVPAF NLATSVNLII AQRLARKLCS HCKKEHEVPR ETLLHEGFPE
490 500 510 520 530 540
DKIGTFKLYS PVGCDHCKNG YKGRVGIYEV VKNTPALQRI IMEEGNSIEI AEQARKEGFN
550 560
DLRTSGLLKA MQGITSLEEV NRVTKD