P22580

PR
Gene name
AMD2 (AMDY, AMDY1, YDR242W, YD8419.09)
Protein name
Probable amidase
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDR242W
EC number
3.5.1.4: In linear amides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P22580

Entry ID Method Resolution Chain Position Source
AF-P22580-F1 Predicted AlphaFoldDB

14 variants for P22580

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-946834 11 V>A No SGRP
s04-946893 31 T>A No SGRP
s04-947020 73 K>R No SGRP
s04-947214 138 E>K No SGRP
s04-947266 155 T>I No SGRP
s04-947313 171 A>T No SGRP
s04-947700 300 V>I No SGRP
s04-947800 333 P>L No SGRP
s04-947964 388 E>K No SGRP
s04-947967 389 I>V No SGRP
s04-948033 411 T>S No SGRP
s04-948345 515 Q>K No SGRP
s04-948409 536 N>S No SGRP
s04-948446 548 K>N No SGRP

No associated diseases with P22580

2 regional properties for P22580

Type Name Position InterPro Accession
conserved_site Amidase, conserved site 207 - 238 IPR020556
domain Amidase signature domain 79 - 539 IPR023631

Functions

Description
EC Number 3.5.1.4 In linear amides
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
amidase activity Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3.
indoleacetamide hydrolase activity Catalysis of the reaction: indole-3-acetamide + H2O = indole-3-acetate + NH3. Indole-3-acetamide is known as IAM and indole-3-acetate as IAA.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTVHSTWKEK VQLKKDQLNS KIKDEWKLNS TTITRLKNDK KNLIKNIDDL CSSSENQITH
70 80 90 100 110 120
STIMALRQAL EAKELSCHEI TAAFCHRAAL IHQVVNCLSE IMFSEALRLA DYYDSNRPAI
130 140 150 160 170 180
LPPLYGIPIS LKDQCNVEGV DTSLGYLCRT FKPKTKNEES LIVSFLRDLG AIIFVKTTVP
190 200 210 220 230 240
SSMMATDTQS NTFGYTYNSI NLSFSSGGSS GGEGSLIGAH GSLLGLGTDI GGSIRIPSSY
250 260 270 280 290 300
QGLFGLKPTF GRVPYLRVDN SFEGRETIPS VIGPLARDLS DLRYFMSCVI NICQPWVQDV
310 320 330 340 350 360
KCIPYHFDSS TSKLHDNYVV GIWYGDGVID PPPSDIRALK TCEDLVNKTK GMKAVKWEPS
370 380 390 400 410 420
SELSRELFDL ANEADVADSG NEIKNEFEIS GEPLLDILKP MVLENGRPPY TVNEWWDLTK
430 440 450 460 470 480
RVYNAQQLMR DYYLSFPESE RPDVIISPTT LMPFRPGDML KTTLRYILLF NVLNFPSLSI
490 500 510 520 530 540
PVGSVDCQID GLMDTTSALN PEDKMIKTYW NDLIQSGEID GFPIGLQVVS PTFNDNEVCK
FASWLFSKI