P22458

PR
Gene name
VTN
Protein name
Vitronectin
Names
VN, Glycoprotein 66, S-protein, Serum-spreading factor
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100009128
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

46-186 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P22458

Entry ID Method Resolution Chain Position Source
AF-P22458-F1 Predicted AlphaFoldDB

No variants for P22458

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P22458

No associated diseases with P22458

11 regional properties for P22458

Type Name Position InterPro Accession
domain Hemopexin-like domain 154 - 469 IPR000585
domain Somatomedin B domain 20 - 63 IPR001212
conserved_site Hemopexin, conserved site 196 - 210 IPR018486-1
conserved_site Hemopexin, conserved site 335 - 350 IPR018486-2
repeat Hemopexin-like repeats 158 - 204 IPR018487-1
repeat Hemopexin-like repeats 203 - 252 IPR018487-2
repeat Hemopexin-like repeats 251 - 305 IPR018487-3
repeat Hemopexin-like repeats 419 - 469 IPR018487-4
domain Somatomedin B domain, chordata 19 - 32 IPR020436-1
domain Somatomedin B domain, chordata 36 - 47 IPR020436-2
domain Somatomedin B domain, chordata 48 - 59 IPR020436-3

Functions

Description
EC Number
Subcellular Localization
  • Secreted, extracellular space
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

3 GO annotations of molecular function

Name Definition
heparin binding Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
polysaccharide binding Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
scavenger receptor activity Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).

2 GO annotations of biological process

Name Definition
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAPLRPIFTL ALLLWVVLAD QESCKDRCTE GFNANRKCQC DELCSYYQSC CADYAAECKP
70 80 90 100 110 120
QVTRGDVFTM PEDEYGPYDY IEQTKDNASV HAQPESPTVG QEPTLSPDLQ TEGGAEPTHE
130 140 150 160 170 180
VPLEPEMETL RPEGEDLQAG TTELGTSASP AEEELCSGKP FDAFTDLKNG SLFAFRGQYC
190 200 210 220 230 240
YELDETAVRP GYPKLIQDVW GIEGPIDAAF TRINCQGKTY LFKGSQYWRF EDGILDPDYP
250 260 270 280 290 300
RNISEGFSGI PDNVDAAFAL PAHSYSGRER VYFFKGDKYW EYQFQQQPSQ EECEGSSLSA
310 320 330 340 350 360
VFEHFAMLHR DSWEDIFKLL FWGRPSGGAR QPQFISRDWH GVPGKVDAAM AGRIYISGLT
370 380 390 400 410 420
PSPSAKKQKS RRRSRKRYRS RYGRGRSQNS RRLSRSISRL WFSSEEVSLG PYNYEDYETS
430 440 450 460 470
WLKPATSEPI QSVYFFSGDK YYRVNLRTQR VDTVNPPYPR SIAQYWLGCP APGGQ