P22427

PR
Gene name
env
Protein name
Envelope glycoprotein
Names
Env polyprotein
Species
Equine infectious anemia virus (isolate P32-1) (EIAV)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

14-89 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for P22427

Entry ID Method Resolution Chain Position Source

No variants for P22427

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P22427

No associated diseases with P22427

1 regional properties for P22427

Type Name Position InterPro Accession
domain Retroviral envelope protein GP41-like 472 - 636 IPR000328

Functions

Description
EC Number
Subcellular Localization
  • [Transmembrane protein]: Virion membrane ; Single-pass type I membrane protein
  • Host cell membrane ; Single-pass type I membrane protein
  • It is probably concentrated at the site of budding and incorporated into the virions possibly by contacts between the cytoplasmic tail of Env and the N-terminus of Gag
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
host cell plasma membrane The plasma membrane surrounding a host cell.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
viral envelope The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins.
virion membrane The lipid bilayer surrounding a virion.

1 GO annotations of molecular function

Name Definition
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

2 GO annotations of biological process

Name Definition
viral entry into host cell The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
virion attachment to host cell The process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVSIAFYGGI PGGISTPITQ QSEKSKCEEN TMFQPYCYNN DSKNSMAESK EARDQEMNLK
70 80 90 100 110 120
EESKEEKRRN DWWKIGMFLL CLAGTTGGIL WWYEGLPQQH YIGLVAIGGR LNGSGQSNAI
130 140 150 160 170 180
ECWGSFPGCR PFQNYFSYET NRSIHMNNNT ATLLEAYHRE ITFIYKSSCT DSDHCQEYQC
190 200 210 220 230 240
KKVNLNSSDS SNSVRVEDVT NTAEYWGFKW LECNQTENFK TILVPENEMV NINDTDTWIP
250 260 270 280 290 300
KGCNETWARV KRCPIDILYG IHPIRLCVQP PFFLVQEKGI ADTSRIGNCG PTIFLGVLED
310 320 330 340 350 360
NKGVVRGDYT ACNVRRLNIN RKDYTGMYQV PIFYTCTFTN ITSCNSEPII SVIMYETNQV
370 380 390 400 410 420
QYLLCNNNNS NNYNCVVQSF GVIGQAHLEL PRPNKRIRNQ SFNQYNCSIN NKTELETWKL
430 440 450 460 470 480
VNTSGITPLP ISSEANTGLI RHKRDFGISA IVAAIVAATA IARSATMSYV ALTEVNKIME
490 500 510 520 530 540
VQNHTFEVEN STLNGMDLIE RQIKILYAMI LQTHADVQLL KERQQVEETF NLIGCIERTH
550 560 570 580 590 600
VFCHTGHPWN MSWGHLNEST QWDDWVSKME DLNQEILTTL HGARNNLAQS MITFNTPDSI
610 620 630 640 650 660
AQFGKDLWSH IGNWIPGLGA SIIKYIVMFL LIYLLLTSSP KILRALWKVT SGAGSSGGRY
670 680 690 700 710 720
LKKKFHHKHA SREDTWDQAQ HNIHLAGVTG GSGDKYYKQK YSRNDWNGES EEYNRRPKSW
730 740 750 760 770 780
VKSIEAFGES YISEKTKGEI SQPGAAINEH KNGSGGNNPH QGSLDLEIRS EGGNIYDCCI
790 800 810 820 830 840
KAQEGTLAIP CCGFPLWLFW GLVIIVGRIA GYGLRGLAVI IRICIRGLNL IFEIIRKMLD
850
YIGRALNPGT SHVSMPQYV