P22353

PR
Gene name
MRPL8 (YJL063C, HRD238, J1125)
Protein name
54S ribosomal protein L8, mitochondrial
Names
Mitochondrial large ribosomal subunit protein bL17m, YmL8
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YJL063C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

92-161 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P22353

Entry ID Method Resolution Chain Position Source
3J6B EM 320 A L 1-238 PDB
5MRC EM 325 A L 2-238 PDB
5MRE EM 375 A L 2-238 PDB
5MRF EM 497 A L 2-238 PDB
AF-P22353-F1 Predicted AlphaFoldDB

5 variants for P22353

Variant ID(s) Position Change Description Diseaes Association Provenance
s10-316280 64 V>A No SGRP
s10-316095 126 L>V No SGRP
s10-315951 174 A>T No SGRP
s10-315861 204 A>T No SGRP
s10-315837 212 A>T No SGRP

No associated diseases with P22353

1 regional properties for P22353

Type Name Position InterPro Accession
domain 54S ribosomal protein L8, C-terminal 130 - 238 IPR040894

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
  • Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site).
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial large ribosomal subunit The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

1 GO annotations of biological process

Name Definition
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTVGIARKLS RDKAHRDALL KNLACQLFQH ESIVSTHAKC KEASRVAERI ITWTKRAITT
70 80 90 100 110 120
SNSVAQAELK SQIQSQLFLA GDNRKLMKRL FSEIAPRYLE RPGGYTRVLR LEPRANDSAP
130 140 150 160 170 180
QSVLELVDSP VMSESHTVNR GNLKMWLLVK SVINDDANQL PHNPLTLQNL HKVAKFKAEA
190 200 210 220 230
QLHGEIMLIK QVLLKEMSLP YDEALENERT QALLKEVYSS SLPKKTKKPS SYVMVPRP