P22194

PR
Gene name
sds22 (SPAC4A8.12c)
Protein name
Protein phosphatase 1 regulatory subunit SDS22
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC4A8.12c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-69 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P22194

Entry ID Method Resolution Chain Position Source
AF-P22194-F1 Predicted AlphaFoldDB

3 variants for P22194

Variant ID(s) Position Change Description Diseaes Association Provenance
I_2573658_T_C 254 Y>C No Jeffares_SNPs
I_2573650_C_T 257 G>R No Jeffares_SNPs
I_2573604_G_T 272 S>Y No Jeffares_SNPs

No associated diseases with P22194

17 regional properties for P22194

Type Name Position InterPro Accession
repeat Leucine-rich repeat 63 - 82 IPR001611-1
repeat Leucine-rich repeat 83 - 104 IPR001611-2
repeat Leucine-rich repeat 105 - 126 IPR001611-3
repeat Leucine-rich repeat 127 - 148 IPR001611-4
repeat Leucine-rich repeat 149 - 170 IPR001611-5
repeat Leucine-rich repeat 171 - 192 IPR001611-6
repeat Leucine-rich repeat 193 - 214 IPR001611-7
repeat Leucine-rich repeat 216 - 237 IPR001611-8
repeat Leucine-rich repeat 238 - 259 IPR001611-9
repeat Leucine-rich repeat 260 - 281 IPR001611-10
repeat Leucine-rich repeat, typical subtype 61 - 86 IPR003591-1
repeat Leucine-rich repeat, typical subtype 103 - 125 IPR003591-2
repeat Leucine-rich repeat, typical subtype 147 - 171 IPR003591-3
repeat Leucine-rich repeat, typical subtype 191 - 214 IPR003591-4
repeat Leucine-rich repeat, typical subtype 236 - 259 IPR003591-5
repeat Leucine-rich repeat, typical subtype 284 - 307 IPR003591-6
domain U2A'/phosphoprotein 32 family A, C-terminal 302 - 320 IPR003603

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein phosphatase type 1 complex A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity.
PTW/PP1 phosphatase complex A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

2 GO annotations of molecular function

Name Definition
protein phosphatase activator activity Binds to and increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.
protein phosphatase regulator activity Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.

5 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
positive regulation of mitotic metaphase/anaphase transition Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
positive regulation of mitotic sister chromatid separation Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation.
signaling The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSNVSSEDGI APETQLIIDD PDVQQIDADE DLLDDVPDDV DCVELIQSRI QSMASLGLER
70 80 90 100 110 120
FKNLQSLCLR QNQIKKIESV PETLTELDLY DNLIVRIENL DNVKNLTYLD LSFNNIKTIR
130 140 150 160 170 180
NINHLKGLEN LFFVQNRIRR IENLEGLDRL TNLELGGNKI RVIENLDTLV NLEKLWVGKN
190 200 210 220 230 240
KITKFENFEK LQKLSLLSIQ SNRITQFENL ACLSHCLREL YVSHNGLTSF SGIEVLENLE
250 260 270 280 290 300
ILDVSNNMIK HLSYLAGLKN LVELWASNNE LSSFQEIEDE LSGLKKLETV YFEGNPLQKT
310 320 330
NPAVYRNKVR LCLPQLRQID ATIIPKTSKQ FP