P22182

PR
Gene name
fgfr1 (fgfra2)
Protein name
Fibroblast growth factor receptor 1
Names
FGFR-1
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:397782
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-230 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

634-659 (Activation loop from InterPro)

Target domain

458-759 (Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P22182

Entry ID Method Resolution Chain Position Source
AF-P22182-F1 Predicted AlphaFoldDB

No variants for P22182

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P22182

No associated diseases with P22182

18 regional properties for P22182

Type Name Position InterPro Accession
domain Protein kinase domain 472 - 761 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 473 - 748 IPR001245
domain Immunoglobulin subtype 2 45 - 107 IPR003598-1
domain Immunoglobulin subtype 2 165 - 233 IPR003598-2
domain Immunoglobulin subtype 2 264 - 344 IPR003598-3
domain Immunoglobulin subtype 39 - 118 IPR003599-1
domain Immunoglobulin subtype 159 - 244 IPR003599-2
domain Immunoglobulin subtype 258 - 355 IPR003599-3
domain Immunoglobulin-like domain 33 - 110 IPR007110-1
domain Immunoglobulin-like domain 154 - 242 IPR007110-2
domain Immunoglobulin-like domain 251 - 353 IPR007110-3
active_site Tyrosine-protein kinase, active site 613 - 625 IPR008266
domain Immunoglobulin I-set 34 - 116 IPR013098-1
domain Immunoglobulin I-set 165 - 243 IPR013098-2
domain Immunoglobulin I-set 258 - 354 IPR013098-3
binding_site Protein kinase, ATP binding site 478 - 508 IPR017441
domain Tyrosine-protein kinase, catalytic domain 472 - 748 IPR020635
domain Fibroblast growth factor receptor 1, catalytic domain 458 - 759 IPR028174

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Nucleus
  • Cytoplasm, cytosol
  • Cytoplasmic vesicle
  • After ligand binding, both receptor and ligand are rapidly internalized
  • Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
fibroblast growth factor receptor activity Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.

1 GO annotations of biological process

Name Definition
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFSGMSLLLW GVLLGAALSV ARPPSTLPDE VAPKTKTEVE PYSAQPGDRI TLQCRLREDV
70 80 90 100 110 120
QSINWVKNGV QLSETNRTRI TGEEIQISNA GPEDNGVYAC VTNGPSRTYT VLCSVNVSDA
130 140 150 160 170 180
LPSAEDDDED DDNSSSEEKA AENSKPNRPL WSHPEKMEKK LHAVPAAKTV KFRCPANGTP
190 200 210 220 230 240
TPTLRWLKNN RAFQQDQRIG GYKVRSQTWS LIMDSVVPSD KGNYTCIVEN KYGAINHTYQ
250 260 270 280 290 300
LDVVERSPHR PILQAGLPAN TSVTVGTTAE FSCKVYSDPQ PHIQWLRHIE INGSRVASDG
310 320 330 340 350 360
FPYVEILKTA GVNTSDKDME VLHLRNVTFE DAGQYTCLAA NSIGISHHSA WLTVLKVEDN
370 380 390 400 410 420
KPALLASPLQ LEIIIYCTGA AFVSAMVVTI IIFKMKHPSK KSDFNSQLAV HKLAKSIPVR
430 440 450 460 470 480
RQVTVSGDSS SSMNSGVILV RRLSSSGTPM LSGLSEYELP EDPRWEVARD RLILGKPLGE
490 500 510 520 530 540
GCFGQVVMAE AIGLDKEKPN KVTKVAVKML KSDASEKDLS DLISEMEMMK MIGKHKNIIN
550 560 570 580 590 600
LLGACTQDGP LYVIVEYTSK GNLREYLRAR RPPAMEYCYN PTCVPDQLLS FKDLVSCAYQ
610 620 630 640 650 660
VARGMDYLAS KKCIHRDLAA RNVLVTEDNI MKIADFGLAR DIHHIDYYKK TTNGRLPVKW
670 680 690 700 710 720
MAPEALFDRI YTHQSDVWSF GVLLWEIFTL GGSPYPGVPM EELFKLLKEG HRMDKPTNCT
730 740 750 760 770 780
NELYMMMKDC WHAMPSQRPT FNQLVEDLDR ILALSSNQEY LDLSMPVNQY SPCFPDTRSS
790 800 810
TCSSGEDSMF SHDPLPDEPC LPKYSNGGLK KR