P22121

PR
Gene name
HSF
Protein name
Heat shock transcription factor
Names
HSTF, Heat shock factor protein, HSF
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_D03322g
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

102-219 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

10 structures for P22121

Entry ID Method Resolution Chain Position Source
1FBQ X-ray 200 A A/B 195-281 PDB
1FBS X-ray 200 A A/B 195-281 PDB
1FBU X-ray 200 A A/B 195-281 PDB
1FYK X-ray 250 A A 193-284 PDB
1FYL X-ray 210 A A/B 193-284 PDB
1FYM X-ray 220 A A/B 193-284 PDB
2HTS X-ray 183 A A 193-281 PDB
3HSF NMR - A 193-281 PDB
3HTS X-ray 175 A B 193-281 PDB
AF-P22121-F1 Predicted AlphaFoldDB

No variants for P22121

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P22121

No associated diseases with P22121

1 regional properties for P22121

Type Name Position InterPro Accession
domain Heat shock factor (HSF)-type, DNA-binding 193 - 297 IPR000232

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-DNA complex A macromolecular complex containing both protein and DNA molecules.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGHNDSVETM DEISNPNNIL LPHDGTGLDA TGISGSQEPY GMVDVLNPDS LKDDSNVDEP
70 80 90 100 110 120
LIEDIVNPSL DPEGVVSAEP SNEVGTPLLQ QPISLDHVIT RPASAGGVYS IGNSSTSSAA
130 140 150 160 170 180
KLSDGDLTNA TDPLLNNAHG HGQPSSESQS HSNGYHKQGQ SQQPLLSLNK RKLLAKAHVD
190 200 210 220 230 240
KHHSKKKLST TRARPAFVNK LWSMVNDKSN EKFIHWSTSG ESIVVPNRER FVQEVLPKYF
250 260 270 280 290 300
KHSNFASFVR QLNMYGWHKV QDVKSGSMLS NNDSRWEFEN ENFKRGKEYL LENIVRQKSN
310 320 330 340 350 360
TNILGGTTNA EVDIHILLNE LETVKYNQLA IAEDLKRITK DNEMLWKENM MARERHQSQQ
370 380 390 400 410 420
QVLEKLLRFL SSVFGPNSAK TIGNGFQPDL IHELSDMQVN HMSNNNHNNT GNINPNAYHN
430 440 450 460 470 480
ETDDPMANVF GPLTPTDQGK VPLQDYKLRP RLLLKNRSMS SSSSSNLNQR QSPQNRIVGQ
490 500 510 520 530 540
SPPPQQQQQQ QQQQGQPQGQ QFSYPIQGGN QMMNQLGSPI GTQVGSPVGS QYGNQYGNQY
550 560 570 580 590 600
SNQFGNQLQQ QTSRPALHHG SNGEIRELTP SIVSSDSPDP AFFQDLQNNI DKQEESIQEI
610 620 630 640 650 660
QDWITKLNPG PGEDGNTPIF PELNMPSYFA NTGGSGQSEQ PSDYGDSQIE ELRNSRLHEP
670
DRSFEEKNNG QKRRRAA