P22118

PR
Gene name
gyrB
Protein name
DNA gyrase subunit B
Names
Species
Neisseria gonorrhoeae
KEGG Pathway
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

353-435 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P22118

Entry ID Method Resolution Chain Position Source
AF-P22118-F1 Predicted AlphaFoldDB

No variants for P22118

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P22118

No associated diseases with P22118

2 regional properties for P22118

Type Name Position InterPro Accession
domain 4Fe-4S ferredoxin-type, iron-sulphur binding domain 25 - 93 IPR017896
conserved_site 4Fe-4S ferredoxin, iron-sulphur binding, conserved site 79 - 90 IPR017900

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTEQKHEEYG ADSIQVLEGL EAVPKRPGMY IGDTQDGSGL HHMVFEVLDN AIDEALAGHC
70 80 90 100 110 120
DKITVTIHAD HSVSVADNGR GMPTGIHPKE GRSAAEVIMT VLHAGGKFDN NSYKISGGLH
130 140 150 160 170 180
GVGVSVVNAL SDWVTLTIYR DGKEHFVRFV RGETEEPLKI VGDSDKKGTT VRFLAGTETF
190 200 210 220 230 240
GNIEYSFDIL AKRIRELSFL NNGVDIELTD ERDGKHESFA LSGGVAGFVQ YMNRKKTPLH
250 260 270 280 290 300
EKIFYAFGEK DGMSVECAMQ WNDSYQESVQ CFTNNIPQRD GGTHLTALRQ VMTRTINSYI
310 320 330 340 350 360
EANEVAKKAK VETAGDDMRE GLTCVLSVKL PDPKFSSQTK DKLVSGEIGP VVNEVINQAL
370 380 390 400 410 420
TDFLEENPNE AKIITGKIVD AARARQAARK AREITRRKGL MDGLGLPGKL ADCQEKDPAL
430 440 450 460 470 480
SELYLVEGNS AGGSAMQGRD RKFQAILPLK GKILNVEKAR FEKMLASQEV ATLITALGAG
490 500 510 520 530 540
IGKEEFNPEK LRYHRIIIMT DADVDGAHIR TLLLTFFYRQ MPDLVERGYI YIAQPPLYKA
550 560 570 580 590 600
KYGKQERYLK DELEKDQWLL GLALEKAKIV SDGRTIEGAE LADTAKQFLL AKTVIEQESR
610 620 630 640 650 660
FVDELVLRAM LHASPIDLTS SENADKAVAE LSGLLDEKEA ALERIEGHEG HQFIKITRKL
670 680 690 700 710 720
HGNVMVSYIE PKFLNSKAYQ TLTQTAAALK GLVGEGAKLY KGENEYDADS FETALDILMS
730 740 750 760 770 780
VAQKGMSIQR YKGLGEMNPE QLWETTMDPT VRRLLKVRIE DRIADEVFVT LMGDEVEPRR
790
AFIENNALIA QNIDA