P21883

PR
Gene name
pdhC (aceC, BSU14600)
Protein name
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
Names
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, E2, S complex, 48 kDa subunit
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU14600
EC number
2.3.1.12: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

58-236 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P21883

Entry ID Method Resolution Chain Position Source
AF-P21883-F1 Predicted AlphaFoldDB

No variants for P21883

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P21883

No associated diseases with P21883

4 regional properties for P21883

Type Name Position InterPro Accession
domain Biotin/lipoyl attachment 1 - 76 IPR000089
domain 2-oxoacid dehydrogenase acyltransferase, catalytic domain 211 - 438 IPR001078
binding_site 2-oxo acid dehydrogenase, lipoyl-binding site 26 - 55 IPR003016
domain Peripheral subunit-binding domain 131 - 169 IPR004167

Functions

Description
EC Number 2.3.1.12 Transferring groups other than amino-acyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
dihydrolipoyllysine-residue acetyltransferase activity Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide.
dihydrolipoyllysine-residue succinyltransferase activity Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide.

2 GO annotations of biological process

Name Definition
glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAFEFKLPDI GEGIHEGEIV KWFVKPNDEV DEDDVLAEVQ NDKAVVEIPS PVKGKVLELK
70 80 90 100 110 120
VEEGTVATVG QTIITFDAPG YEDLQFKGSD ESDDAKTEAQ VQSTAEAGQD VAKEEQAQEP
130 140 150 160 170 180
AKATGAGQQD QAEVDPNKRV IAMPSVRKYA REKGVDIRKV TGSGNNGRVV KEDIDSFVNG
190 200 210 220 230 240
GAQEAAPQET AAPQETAAKP AAAPAPEGEF PETREKMSGI RKAIAKAMVN SKHTAPHVTL
250 260 270 280 290 300
MDEVDVTNLV AHRKQFKQVA ADQGIKLTYL PYVVKALTSA LKKFPVLNTS IDDKTDEVIQ
310 320 330 340 350 360
KHYFNIGIAA DTEKGLLVPV VKNADRKSVF EISDEINGLA TKAREGKLAP AEMKGASCTI
370 380 390 400 410 420
TNIGSAGGQW FTPVINHPEV AILGIGRIAE KAIVRDGEIV AAPVLALSLS FDHRMIDGAT
430 440
AQNALNHIKR LLNDPQLILM EA