P21795

PR
Gene name
Protein name
L-lactate 2-monooxygenase
Names
LMO, Lactate monooxygenase
Species
Mycolicibacterium smegmatis (Mycobacterium smegmatis)
KEGG Pathway
EC number
1.13.12.4: With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

82-166 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P21795

Entry ID Method Resolution Chain Position Source
6DVH X-ray 170 A A/B/C/D/E/F 1-394 PDB
6DVI X-ray 230 A A/B/C/D/E/F 1-394 PDB
AF-P21795-F1 Predicted AlphaFoldDB

No variants for P21795

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P21795

No associated diseases with P21795

4 regional properties for P21795

Type Name Position InterPro Accession
domain FMN-dependent dehydrogenase 34 - 390 IPR000262
active_site FMN-dependent alpha-hydroxy acid dehydrogenase, active site 289 - 295 IPR008259
domain Lactate 2-monooxygenase, FMN-binding domain 7 - 390 IPR037350
domain FMN hydroxy acid dehydrogenase domain 19 - 394 IPR037396

Functions

Description
EC Number 1.13.12.4 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
FMN binding Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
lactate 2-monooxygenase activity Catalysis of the reaction: (S)-lactate + O(2) = acetate + CO(2) + H(2)O.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSNWGDYENE IYGQGLVGVA PTLPMSYADW EAHAQQALPP GVLSYVAGGS GDEHTQRANV
70 80 90 100 110 120
EAFKHWGLMP RMLMAATERD LSVELWGKTW AAPMFFAPIG VIALCAQDGH GDAASAQASA
130 140 150 160 170 180
RTGVPYITST LAVSSLEDIR KHAGDTPAYF QLYYPEDRDL AESFIRRAEE AGYDGLVITL
190 200 210 220 230 240
DTWIFGWRPR DLTISNFPFL RGLCLTNYVT DPVFQKKFKA HSGVEAEGLR DNPRLAADFW
250 260 270 280 290 300
HGLFGHSVTW EDIDWVRSIT KMPVILKGIQ HPDDARRAVD SGVDGIYCSN HGGRQANGGL
310 320 330 340 350 360
PALDCLPEVV KASGDTPVLF DSGIRTGADV VKALAMGASA VGIGRPYAWG AALGGSKGIE
370 380 390
HVARSLLAEA DLIMAVDGYR NLKELTIDAL RPTR