P21658
SS
Gene name |
Fgf6 (Fgf-6, Hstf2) |
Protein name |
Fibroblast growth factor 6 |
Names |
FGF-6 , Heparin secretory-transforming protein 2 , HST-2 , HSTF-2 , Heparin-binding growth factor 6 , HBGF-6 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14177 |
EC number |
|
Protein Class |
|
Descriptions
The mammalian fibroblast growth factor (FGF)1 family contains at least 22 distinct polypeptides (FGF1–FGF22) that are expressed in a specific spatial and temporal pattern. FGF9 was originally described as a glia-activating factor and is expressed in the nervous system as a potent mitogen for glia cells. FGF9 adopts a beta-trefoil fold similar to other FGFs, but the N- and C-terminal regions outside the beta-trefoil core are ordered (typical FGFs have disordered tails) and involved in reversible dimerization. Due to the dimerization, a significant surface area is buried in the dimer interface that occludes a major receptor binding site of FGF9 within the beta-trefoil core. Sequence alignment of FGFs shows that most of the residues that participate in this interface in FGF9 are conserved in FGF16, suggesting that FGF16 may also dimerize for autoinhibition.
Autoinhibitory domains (AIDs)
Target domain |
85-207 (beta-trefoil core) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P21658
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P21658-F1 | Predicted | AlphaFoldDB |
6 variants for P21658
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388857352 | 105 | R>S | No | EVA | |
| rs3388860052 | 107 | S>N | No | EVA | |
| rs3388863806 | 146 | R>G | No | EVA | |
| rs3388869313 | 166 | N>T | No | EVA | |
| rs3388866281 | 175 | L>Q | No | EVA | |
| rs3388839671 | 187 | G>A | No | EVA |
No associated diseases with P21658
13 regional properties for P21658
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Dbl homology (DH) domain | 193 - 371 | IPR000219 |
| domain | SH2 domain | 661 - 757 | IPR000980 |
| conserved_site | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | 320 - 345 | IPR001331 |
| domain | SH3 domain | 576 - 642 | IPR001452-1 |
| domain | SH3 domain | 806 - 867 | IPR001452-2 |
| domain | Calponin homology domain | 1 - 120 | IPR001715 |
| domain | Pleckstrin homology domain | 400 - 504 | IPR001849 |
| domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | 513 - 562 | IPR002219 |
| domain | Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain | 19 - 103 | IPR022613 |
| domain | VAV2 protein, second SH3 domain | 809 - 866 | IPR035732 |
| domain | VAV2 protein, first SH3 domain | 580 - 639 | IPR035733 |
| domain | VAV2, SH2 domain | 657 - 759 | IPR035880 |
| domain | Vav, PH domain | 384 - 506 | IPR037832 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| sarcolemma | The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| fibroblast growth factor receptor binding | Binding to a fibroblast growth factor receptor (FGFR). |
| growth factor activity | The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| animal organ morphogenesis | Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. |
| cartilage condensation | The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes. |
| cell differentiation | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| fibroblast growth factor receptor signaling pathway | The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. |
| myoblast differentiation | The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. |
| positive regulation of cell division | Any process that activates or increases the frequency, rate or extent of cell division. |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of protein phosphorylation | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
| regulation of cell migration | Any process that modulates the frequency, rate or extent of cell migration. |
28 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P48801 | FGF3 | Fibroblast growth factor 3 | Gallus gallus (Chicken) | SS |
| P08620 | FGF4 | Fibroblast growth factor 4 | Homo sapiens (Human) | PR |
| Q9NP95 | FGF20 | Fibroblast growth factor 20 | Homo sapiens (Human) | SS |
| Q9HCT0 | FGF22 | Fibroblast growth factor 22 | Homo sapiens (Human) | SS |
| O15520 | FGF10 | Fibroblast growth factor 10 | Homo sapiens (Human) | SS |
| Q92914 | FGF11 | Fibroblast growth factor 11 | Homo sapiens (Human) | SS |
| P11487 | FGF3 | Fibroblast growth factor 3 | Homo sapiens (Human) | SS |
| P31371 | FGF9 | Fibroblast growth factor 9 | Homo sapiens (Human) | EV |
| O43320 | FGF16 | Fibroblast growth factor 16 | Homo sapiens (Human) | EV SS |
| Q9NSA1 | FGF21 | Fibroblast growth factor 21 | Homo sapiens (Human) | PR |
| P10767 | FGF6 | Fibroblast growth factor 6 | Homo sapiens (Human) | SS |
| O35565 | Fgf10 | Fibroblast growth factor 10 | Mus musculus (Mouse) | SS |
| P11403 | Fgf4 | Fibroblast growth factor 4 | Mus musculus (Mouse) | PR |
| P54130 | Fgf9 | Fibroblast growth factor 9 | Mus musculus (Mouse) | SS |
| Q9ESL8 | Fgf16 | Fibroblast growth factor 16 | Mus musculus (Mouse) | SS |
| Q9ESL9 | Fgf20 | Fibroblast growth factor 20 | Mus musculus (Mouse) | SS |
| Q9ESS2 | Fgf22 | Fibroblast growth factor 22 | Mus musculus (Mouse) | SS |
| Q9JJN1 | Fgf21 | Fibroblast growth factor 21 | Mus musculus (Mouse) | PR |
| P61329 | Fgf12 | Fibroblast growth factor 12 | Mus musculus (Mouse) | PR |
| P05524 | Fgf3 | Fibroblast growth factor 3 | Mus musculus (Mouse) | SS |
| Q95L12 | FGF9 | Fibroblast growth factor 9 | Sus scrofa (Pig) | SS |
| Q9EST9 | Fgf20 | Fibroblast growth factor 20 | Rattus norvegicus (Rat) | SS |
| O54769 | Fgf16 | Fibroblast growth factor 16 | Rattus norvegicus (Rat) | SS |
| P36364 | Fgf9 | Fibroblast growth factor 9 | Rattus norvegicus (Rat) | SS |
| P70492 | Fgf10 | Fibroblast growth factor 10 | Rattus norvegicus (Rat) | SS |
| Q6PBT8 | fgf1 | Putative fibroblast growth factor 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q2HXK8 | fgf16 | Fibroblast growth factor 16 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| P48802 | fgf3 | Fibroblast growth factor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALGQRLFIT | MSRGAGRVQG | TLQALVFLGV | LVGMVVPSPA | GARANGTLLD | SRGWGTLLSR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SRAGLAGEIS | GVNWESGYLV | GIKRQRRLYC | NVGIGFHLQV | PPDGRISGTH | EENPYSLLEI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| STVERGVVSL | FGVKSALFIA | MNSKGRLYTT | PSFHDECKFR | ETLLPNNYNA | YESDLYRGTY |
| 190 | 200 | ||||
| IALSKYGRVK | RGSKVSPIMT | VTHFLPRI |