P21592

PR
Gene name
COX10 (YPL172C)
Protein name
Protoheme IX farnesyltransferase, mitochondrial
Names
5'-NT, Ecto-5'-nucleotidase, 5'-NT, Ecto-5'-nucleotidase, Heme O synthase
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YPL172C
EC number
2.5.1.141: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

52-168 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P21592

Entry ID Method Resolution Chain Position Source
AF-P21592-F1 Predicted AlphaFoldDB

10 variants for P21592

Variant ID(s) Position Change Description Diseaes Association Provenance
s16-225685 19 N>S No SGRP
s16-225500 81 V>F No SGRP
s16-225500 81 V>I No SGRP
s16-225485 86 M>L No SGRP
s16-225451 97 T>N No SGRP
s16-225418 108 S>N No SGRP
s16-225361 127 R>K No SGRP
s16-225218 175 P>A No SGRP
s16-225205 179 N>S No SGRP
s16-225064 226 T>I No SGRP

No associated diseases with P21592

1 regional properties for P21592

Type Name Position InterPro Accession
conserved_site UbiA prenyltransferase conserved site 199 - 221 IPR030470

Functions

Description
EC Number 2.5.1.141 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
  • Mitochondrion
  • Mitochondrion membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
farnesyltranstransferase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
protoheme IX farnesyltransferase activity Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate.

2 GO annotations of biological process

Name Definition
heme A biosynthetic process The chemical reactions and pathways resulting in the formation of heme A, a derivative of heme found in cytochrome aa3.
heme biosynthetic process The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSYFPRTYAH LMRNVLAHNK GNIYLQIGTQ LHDTQIKIRF NGVRYISRNH GGKQQHINTA
70 80 90 100 110 120
PIEFTPNFGY GDRTSNCNKK VESTAMKTLR CTDDISTSSG SEATTDASTQ LPFNVKLVDP
130 140 150 160 170 180
MVRKSKRPSH AISEGLNMKT LKKKVIMPYL QLTKPRLTIL VMLSAICSYA LSPYPASVNE
190 200 210 220 230 240
LLCLTVGTTL CSGSANAINM GREPEFDRQM VRTQARPVVR GDVTPTQAFE FAALIGTLGV
250 260 270 280 290 300
SILYFGVNPT VAILGASNIA LYGWAYTSMK RKHIINTWLG ALVGMVPPLM GWAAASPLSH
310 320 330 340 350 360
PGSWCLAGLL FAWQFPHFNT LSHNIRNEYK NAGYVMTAWK NPLLNARVSL RYSILMFPLC
370 380 390 400 410 420
FGLSYFNITD WYYQIDSGLI NAWLTFWAFK FYWQQRINYS AKTLKDNVKF NKGLSVANIY
430 440 450 460
ARKTFMASVL HLPAILILAI IHKKGRWDWI YPGEAKRPQE RF