P21556

PR
Gene name
PTAFR
Protein name
Platelet-activating factor receptor
Names
PAF-R, PAFr
Species
Cavia porcellus (Guinea pig)
KEGG Pathway
cpoc:100720710
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

284-342 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P21556

Entry ID Method Resolution Chain Position Source
AF-P21556-F1 Predicted AlphaFoldDB

No variants for P21556

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P21556

No associated diseases with P21556

1 regional properties for P21556

Type Name Position InterPro Accession
domain GPCR, rhodopsin-like, 7TM 32 - 293 IPR017452

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
lipopolysaccharide binding Binding to a lipopolysaccharide.
lipopolysaccharide immune receptor activity Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate an innate immune response. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.
platelet activating factor receptor activity Combining with platelet activating factor to initiate a change in cell activity.

4 GO annotations of biological process

Name Definition
chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
inositol trisphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MELNSSSRVD SEFRYTLFPI VYSIIFVLGI IANGYVLWVF ARLYPSKKLN EIKIFMVNLT
70 80 90 100 110 120
VADLLFLITL PLWIVYYSNQ GNWFLPKFLC NLAGCLFFIN TYCSVAFLGV ITYNRFQAVK
130 140 150 160 170 180
YPIKTAQATT RKRGIALSLV IWVAIVAAAS YFLVMDSTNV VSNKAGSGNI TRCFEHYEKG
190 200 210 220 230 240
SKPVLIIHIC IVLGFFIVFL LILFCNLVII HTLLRQPVKQ QRNAEVRRRA LWMVCTVLAV
250 260 270 280 290 300
FVICFVPHHM VQLPWTLAEL GMWPSSNHQA INDAHQVTLC LLSTNCVLDP VIYCFLTKKF
310 320 330 340
RKHLSEKLNI MRSSQKCSRV TTDTGTEMAI PINHTPVNPI KN