AiPD: Autoinhibited Protein Database

Gene name	RNR1 (CRT7, RIR1, SDS12, YER070W)
Protein name	Ribonucleoside-diphosphate reductase large chain 1
Names	Ribonucleotide reductase R1 subunit 1, Ribonucleotide reductase large subunit 1
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YER070W
EC number	1.17.4.1: With a disulfide as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

725-888 (Predicted disordered autoinhibitory region) PR

725-888 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
1ZYZ	X-ray	290 A	A/B	1-888	PDB
1ZZD	X-ray	260 A	A	1-888	PDB
2CVS	X-ray	260 A	A	1-888	PDB
2CVT	X-ray	320 A	A	1-888	PDB
2CVU	X-ray	290 A	A	1-888	PDB
2CVV	X-ray	290 A	A	1-888	PDB
2CVW	X-ray	240 A	A	1-888	PDB
2CVX	X-ray	220 A	A	1-888	PDB
2CVY	X-ray	240 A	A	1-888	PDB
2EUD	X-ray	230 A	A	1-888	PDB
2ZLF	X-ray	259 A	A	1-888	PDB
2ZLG	X-ray	252 A	A	1-888	PDB
3K8T	X-ray	210 A	A	1-888	PDB
3PAW	X-ray	661 A	A/B/C/D	1-888	PDB
3RSR	X-ray	230 A	A	1-888	PDB
3S87	X-ray	225 A	A	1-888	PDB
3S8A	X-ray	290 A	A	1-888	PDB
3S8B	X-ray	280 A	A	1-888	PDB
3S8C	X-ray	277 A	A	1-888	PDB
3TB9	X-ray	253 A	A	1-888	PDB
3TBA	X-ray	280 A	A	1-888	PDB
AF-P21524-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s05-300620	558	E>G	No	SGRP
s05-300736	597	V>I	No	SGRP
s05-301504	853	K>E	No	SGRP

Type	Name	Position	InterPro Accession
domain	Ribonucleotide reductase large subunit, C-terminal	216 - 742	IPR000788
domain	ATP-cone domain	1 - 92	IPR005144
domain	Ribonucleotide reductase, class I, alpha subunit, C-terminal	145 - 746	IPR013346
domain	Ribonucleotide reductase large subunit, N-terminal	142 - 212	IPR013509

		Description
EC Number	1.17.4.1	With a disulfide as acceptor
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoside-diphosphate reductase complex	An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding	Binding to an identical protein or proteins.
nucleotide binding	Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.

Name	Definition
deoxyribonucleotide biosynthetic process	The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
DNA replication	The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P48591	RnrL	Ribonucleoside-diphosphate reductase large subunit	Drosophila melanogaster (Fruit fly)	PR