P21405

PR
Gene name
ORF2A-2B
Protein name
Replicase polyprotein P2AB
Names
Species
Southern cowpea mosaic virus (SCPMV) (Southern bean mosaic virus (strain cowpea))
KEGG Pathway
vg:1481843
EC number
2.7.7.48: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

882-953 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for P21405

Entry ID Method Resolution Chain Position Source

No variants for P21405

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P21405

No associated diseases with P21405

2 regional properties for P21405

Type Name Position InterPro Accession
domain Peptidase S39B, luteovirus 135 - 330 IPR000382
domain RNA-directed RNA polymerase, catalytic domain 694 - 808 IPR007094

Functions

Description
EC Number 2.7.7.48 Nucleotidyltransferases
Subcellular Localization
  • [N-terminal protein]: Host membrane ; Multi-pass membrane protein
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
host cell membrane Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

4 GO annotations of molecular function

Name Definition
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.
serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

4 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
RNA-protein covalent cross-linking The formation of a covalent cross-link between RNA and a protein.
viral RNA genome replication The replication of a viral RNA genome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYRPSCLSYV LLVANMWSFA VCANAFIYGS YDPSHNIPIV ALMTLCATGL WLSTSVVSFG
70 80 90 100 110 120
IRYVRVRVSP EKTQNRTIYV SSGLPHFDPV YGVVKKCEPM GGGPAIELQV NPSWIHLLPT
130 140 150 160 170 180
SPAINKVEVG QESAILGSTY SVVETGGEPK SLVAVKSGDS TLGFGARVYH EGMDVLMVPH
190 200 210 220 230 240
HVWYNDKPHT ALAKNGRSVD TEDWEVEAAC ADPRIDFVLV KVPTAVWAKL AVRSTKVLAP
250 260 270 280 290 300
VHGTAVQTFG GQDSKQLFSG LGKAKALDNA WEFTHTAPTA KGWSGTPLYT RDGIVGMHTG
310 320 330 340 350 360
YVDIGTSNRA INMHFIMSCL VSKMETLPPE LGYREISLED VGLRSFEFLE VEIENRGKVK
370 380 390 400 410 420
LGKREFAWVP KGKAWADMLD DDDLPLPPKM VNGNLVWADA QESFDGALPL NLLAGGRTQC
430 440 450 460 470 480
LAAQIELGDY KFSCGPTHET GGMPFRNCGS STCKFREVSR KPVADAVTAA TKVFPELSEL
490 500 510 520 530 540
GWPERGSGAE IGSLLLQAGK FVPTKAPSNL EQAYNNLLSR YPRSKPLACF RQGTWSFDAI
550 560 570 580 590 600
FEQVVSKATS AEINQKASPG VPLSRLATTN KDLMAQHMQF VAACVTGRVP LLASFEDIHA
610 620 630 640 650 660
LSPTEMVEMG LCDPVRLFVK QEPHPSRKLK EGRYRLISSV SIVDQLVERM LFGAQNELEI
670 680 690 700 710 720
AEWQSIPSKP GMGLSVIHQA DAIFRDLRVK HTVCPAAEAD ISGFDWSVQD WELWADVEMR
730 740 750 760 770 780
IVLGSFPPMM ARAARNRFSC FMNSVLQLSN GQLLQQELPG IMKSGSYCTS STNSRIRCLM
790 800 810 820 830 840
AELIGSPWCI AMGDDSVEGF VEGAREKYAG LGHLCKDYKP CATTPTGQLY AVEFCSHVIK
850 860 870 880 890 900
RNKAFLTSWP KTLYRFLSTP RETLEDLERE LASSPMWHKI QSYVRSIPSP DKTARDKSIC
910 920 930 940 950
NGYPLDQEAI STSYSEYSSK SASAEATREA ACCAGAQAYP SWGIHGPYCS GDHGEA