P21328

PR
Gene name
pol
Protein name
RNA-directed DNA polymerase from mobile element jockey
Names
Reverse transcriptase
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
EC number
2.7.7.49: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

346-415 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P21328

Entry ID Method Resolution Chain Position Source
AF-P21328-F1 Predicted AlphaFoldDB

No variants for P21328

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P21328

No associated diseases with P21328

2 regional properties for P21328

Type Name Position InterPro Accession
domain Reverse transcriptase domain 483 - 757 IPR000477
domain Endonuclease/exonuclease/phosphatase 105 - 218 IPR005135

Functions

Description
EC Number 2.7.7.49 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
RNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTQPTLKIGL WNARGLTRGS EELRIFLSDH DIDVMLTTET HMRVGQRIYL PGYLMYHAHH
70 80 90 100 110 120
PSGNSRGGSA VIIKSRLCHS PLTPISTNDR QIARVHLQTS VGTVTVAAVY LPPAERWIVD
130 140 150 160 170 180
DFKSMFAALG NKFIAGGDYN AKHAWWGNPR SCPRGKMLQE VIAHGQYQVL ATGEPTFYSY
190 200 210 220 230 240
NPLLTPSALD FFITCGYGMG RLDVQTLQEL SSDHLPILAV LHATPLKKPQ RVRLLAHNAD
250 260 270 280 290 300
INIFKTHLEQ LSEVNMQILE AVDIDNATSL FMSKLSEAAQ LAAPRNRHEV EAFRPLQLPS
310 320 330 340 350 360
SILALLRLKR RVRKEYARTG DPRMQQIHSR LANCLHKALA RRKQAQIDTF LDNLGADAST
370 380 390 400 410 420
NYSLWRITKR FKAQPTPKSA IKNPSGGWCR TSLEKTEVFA NNLEQRFTPY NYAPESLCRQ
430 440 450 460 470 480
VEEYLESPFQ MSLPLSAVTL EEVKNLIAKL PLKKAPGEDL LDNRTIRLLP DQALQFLALI
490 500 510 520 530 540
FNSVLDVGYF PKAWKSASII MIHKTGKTPT DVDSYRPTSL LPSLGKIMER LILNRLLTCK
550 560 570 580 590 600
DVTKAIPKFQ FGFRLQHGTP EQLHRVVNFA LEAMENKEYA VGAFLDIQQA FDRVWHPGLL
610 620 630 640 650 660
YKAKRLFPPQ LYLVVKSFLE ERTFHVSVDG YKSSIKPIAA GVPQGSVLGP TLYSVFASDM
670 680 690 700 710 720
PTHTPVTEVD EEDVLIATYA DDTAVLTKSK SILAATSGLQ EYLDAFQQWA ENWNVRINAE
730 740 750 760 770 780
KCANVTFANR TGSCPGVSLN GRLIRHHQAY KYLGITLDRK LTFSRHITNI QQAFRTKVAR
790 800 810 820 830 840
MSWLIAPRNK LSLGCKVNIY KSILAPCLFY GLQVYGIAAK SHLNKIRILQ AKTLRRISGA
850 860 870 880 890 900
PWYMRTRDIE RDLKVPKLGD KLQNIAQKYM ERLNVHPNSL ARKLGTAAVV NADPRTRVKR
910
RLKRHHPHDL PNLVLT