P20951

PR
Gene name
Protein name
RNA replication protein
Names
176 kDa protein, ORF1 protein
Species
Papaya mosaic potexvirus (PMV)
KEGG Pathway
vg:1494026
EC number
2.7.7.48: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

407-555 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for P20951

Entry ID Method Resolution Chain Position Source

No variants for P20951

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P20951

No associated diseases with P20951

5 regional properties for P20951

Type Name Position InterPro Accession
domain RNA-dependent RNA polymerase, alsuviricetes 1225 - 1438 IPR001788
domain Alphavirus-like methyltransferase (MT) domain 39 - 329 IPR002588
domain Oxoglutarate/iron-dependent dioxygenase 599 - 690 IPR005123
domain RNA-directed RNA polymerase, catalytic domain 1324 - 1431 IPR007094
domain (+) RNA virus helicase core domain 793 - 1082 IPR027351

Functions

Description
EC Number 2.7.7.48 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
mRNA methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

3 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
viral RNA genome replication The replication of a viral RNA genome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MANLRSVFEQ LNDVSLRAVI QEEAYRDIKL TIKETKTYNP YAHPVAVADS LEKLGIETNP
70 80 90 100 110 120
FAVKAHTHAA AKTIELDMYK IVSFYLPKEN PTTFMFMKRS KLQYFRRGPQ QKDVFLNAHI
130 140 150 160 170 180
EPKDVARYDV DTLFDKNVTP QITTNTAFMG DTLHFLPLTA IERIFKSSPK LQTLYATMVL
190 200 210 220 230 240
PPEALHRLHS LHPGIYELEF HQEHFIYKPG GHAGAAYIHK YEQLEWIKVG RFKWADEKGL
250 260 270 280 290 300
THMVTSQILE TKGANHLFIF QRGRFLTPEL RCFSTETKYV TMPPIFLPKQ FNARLPIKKT
310 320 330 340 350 360
TAQQLFLYVK SVKNVTERDI WAKMRQLLKT SELQDYNPRE VTLLVNYFLL IARLRSETCF
370 380 390 400 410 420
DNVLSGGMFK KLFKPFIAWW EIQKHKIFGN EEFEQLMEAL EWVDVTLTYP TKTFDNRGWV
430 440 450 460 470 480
VKLEARRGYE WFADEMHKPK GPELNLEEKK TDPDAASYEK YLKALSLLQK EPEVMEAKEA
490 500 510 520 530 540
EATDEPQRPE VKEEQAEAST SGRAEEIQED PATKKGKEEP NPNRDLLCPC GLHLKIKNAE
550 560 570 580 590 600
FPELPVLDHP DHLTGRKAWF FSKDGKPYSY TGGSHASRGW PNWLEKILAA IEIKEPLPEF
610 620 630 640 650 660
NQCLVQQFKL QAAIPFHRDD EPCYPKGHQV LTINHSGECL TQIACQKGKA SITMGFGDYY
670 680 690 700 710 720
LSPVGFQESH KHAVSNTTGG RVSLTFRCTV QQNKFNDDGS MEALDNLPWK AWIPKLQNLG
730 740 750 760 770 780
FQGRQLQYDP NGALISPIEE IRSMPKCKPE GVPEVVYKTL DGLARAPTPY SPNPIRARAY
790 800 810 820 830 840
TSDVKNCRIG ALLRQQGKEW GCRFDALVEA GKRELAISVI HGAGGSGKSQ ALQTLIKDNP
850 860 870 880 890 900
ELDITVVLPT NELRLDWLRK LPKAPQEKFK TFEKALLAPP TPIVIFDDYG KLPAGYVEAF
910 920 930 940 950 960
CLYFSTVQLI ILTGDCKQSV HHESNENATT SSIEPLVKEA SELCRYYINA THRNKKDLAN
970 980 990 1000 1010 1020
KLGVYSEKTG LTEVTHGTTP IPGLHMLVPS LYKKQAFSEM GHKVSTYAGC QGITAPKIQI
1030 1040 1050 1060 1070 1080
LLTEETSLCS REVLYTALSR AVHSIHFVNA SPNNQAFWKK LECTPYLKAF LSTLREEVAQ
1090 1100 1110 1120 1130 1140
PIEEKKAEPT PVEPPRTHIA KEDAMVEYEN VIEKMPEKHE REIFSEKHGH SNCVQTEDPF
1150 1160 1170 1180 1190 1200
IQMFSHQQAK DDTLLWATIE ARLVISNPKA NWQEYLEKRP VGEVLFESYK RAMHLPKMPI
1210 1220 1230 1240 1250 1260
PFEEDLWNSS MHEVQKTYLS KPENMIKNGM ARQSPDYDPN VISLFLKSQW VKKMEKLGAI
1270 1280 1290 1300 1310 1320
KIKPGQTIAS FHQATVMLFG TMARYMRRMR EVFQPAHIRI NCEMTPEDLS SWAAGEGGHW
1330 1340 1350 1360 1370 1380
KFKGPSLAND FTAFDQSQDG AMLQFEILKA RHHSIPEDIL DAYLTIKTNS KIFLGTLAIM
1390 1400 1410 1420 1430 1440
RLTGEGPTFD ANTECNIAFT HTKFNIPEGT AQLYAGDDSA IDGLPALRPS FKMIEQKLTL
1450 1460 1470 1480 1490 1500
RSKPQVALQQ KGDWAEFCGF RITPKGLIKD PKKLHASWML EKKKGNVKNV LRSYELDLAL
1510 1520 1530 1540
AYQHKDSLHE LLSEEELKYH YETVRSIVKS GGGGVLNTYI SKDESLY