P20917

PR
Gene name
Mag
Protein name
Myelin-associated glycoprotein
Names
Siglec-4a
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:17136
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

569-626 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for P20917

Entry ID Method Resolution Chain Position Source
5LF5 X-ray 380 A A 20-508 PDB
5LFR X-ray 212 A A/B 20-325 PDB
5LFU X-ray 430 A A 20-508 PDB
5LFV X-ray 230 A A/B 20-325 PDB
6GZJ X-ray 198 A B 573-627 PDB
6GZL X-ray 195 A B 605-621 PDB
AF-P20917-F1 Predicted AlphaFoldDB

28 variants for P20917

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388899545 21 H>Q No EVA
rs3388873230 24 A>D No EVA
rs3388898818 135 L>M No EVA
rs3397339331 165 C>* No EVA
rs3412177956 165 C>G No EVA
rs3397795215 224 T>I No EVA
rs3388899591 226 L>* No EVA
rs261533695 281 R>K No EVA
rs49440298 286 K>E No EVA
rs3388893289 302 V>I No EVA
rs3388902685 325 A>T No EVA
rs3388902663 330 T>I No EVA
rs3388899573 336 V>M No EVA
rs3388886813 414 I>K No EVA
rs3388873277 419 S>* No EVA
rs3388882433 425 R>I No EVA
rs3388882451 428 V>L No EVA
rs3388873271 481 Q>* No EVA
rs3388896115 502 P>L No EVA
rs3388902716 504 Q>H No EVA
rs3388898746 518 G>C No EVA
rs47451860 546 S>P No EVA
rs3388858429 555 H>L No EVA
rs3397330721 570 K>Q No EVA
rs3397574851 571 Y>S No EVA
rs45996260 574 E>K No EVA
rs227369433 591 S>P No EVA
rs3388897102 607 P>S No EVA

No associated diseases with P20917

9 regional properties for P20917

Type Name Position InterPro Accession
domain Immunoglobulin subtype 2 252 - 312 IPR003598-1
domain Immunoglobulin subtype 2 338 - 399 IPR003598-2
domain Immunoglobulin subtype 27 - 135 IPR003599-1
domain Immunoglobulin subtype 144 - 237 IPR003599-2
domain Immunoglobulin subtype 246 - 323 IPR003599-3
domain Immunoglobulin subtype 332 - 410 IPR003599-4
domain Immunoglobulin-like domain 239 - 321 IPR007110-1
domain Immunoglobulin-like domain 329 - 408 IPR007110-2
domain CD80-like, immunoglobulin C2-set 142 - 219 IPR013162

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Membrane raft
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
compact myelin The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
mesaxon Portion of the ensheathing process (either myelin or non-myelin) where the enveloping lips of the ensheathing cell come together so that their apposed plasma membranes run parallel to each other, separated by a cleft 12 nm wide.
myelin sheath An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
myelin sheath adaxonal region The region of the myelin sheath nearest to the axon.
paranode region of axon An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
Schmidt-Lanterman incisure Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier.

6 GO annotations of molecular function

Name Definition
carbohydrate binding Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
ganglioside GT1b binding Binding to ganglioside GT1b.
protein homodimerization activity Binding to an identical protein to form a homodimer.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
sialic acid binding Binding to a sialic acid, a N- or O- substituted derivative of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria.
signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

14 GO annotations of biological process

Name Definition
axon regeneration The regrowth of axons following their loss or damage.
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cell-cell adhesion via plasma-membrane adhesion molecules The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane.
cellular response to mechanical stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
central nervous system myelin formation The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system.
central nervous system myelination The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
myelination The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
negative regulation of axon extension Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.
negative regulation of neuron apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
negative regulation of neuron differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
negative regulation of neuron projection development Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
positive regulation of astrocyte differentiation Any process that activates or increases the frequency, rate or extent of astrocyte differentiation.
positive regulation of myelination Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
transmission of nerve impulse The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P20916 MAG Myelin-associated glycoprotein Homo sapiens (Human) PR
10 20 30 40 50 60
MIFLATLPLF WIMISASRGG HWGAWMPSTI SAFEGTCVSI PCRFDFPDEL RPAVVHGVWY
70 80 90 100 110 120
FNSPYPKNYP PVVFKSRTQV VHESFQGRSR LLGDLGLRNC TLLLSTLSPE LGGKYYFRGD
130 140 150 160 170 180
LGGYNQYTFS EHSVLDIVNT PNIVVPPEVV AGTEVEVSCM VPDNCPELRP ELSWLGHEGL
190 200 210 220 230 240
GEPTVLGRLR EDEGTWVQVS LLHFVPTREA NGHRLGCQAA FPNTTLQFEG YASLDVKYPP
250 260 270 280 290 300
VIVEMNSSVE AIEGSHVSLL CGADSNPPPL LTWMRDGMVL REAVAKSLYL DLEEVTPGED
310 320 330 340 350 360
GVYACLAENA YGQDNRTVEL SVMYAPWKPT VNGTVVAVEG ETVSILCSTQ SNPDPILTIF
370 380 390 400 410 420
KEKQILATVI YESQLQLELP AVTPEDDGEY WCVAENQYGQ RATAFNLSVE FAPIILLESH
430 440 450 460 470 480
CAAARDTVQC LCVVKSNPEP SVAFELPSRN VTVNETEREF VYSERSGLLL TSILTIRGQA
490 500 510 520 530 540
QAPPRVICTS RNLYGTQSLE LPFQGAHRLM WAKIGPVGAV VAFAILIAIV CYITQTRRKK
550 560 570 580 590 600
NVTESSSFSG GDNPHVLYSP EFRISGAPDK YESEKQRLGS ERRLLGLRGE SPELDLSYSH
610 620
SDLGKRPTKD SYTLTEELAE YAEIRVK