P20911

PR
Gene name
cdk7 (mo15)
Protein name
Cyclin-dependent kinase 7
Names
40 kDa protein kinase, CDC2/CDK2,4-activating kinase, Cell division protein kinase 7, P40 MO15
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:399461
EC number
2.7.11.23: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

276-352 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

160-183 (Activation loop from InterPro)

Target domain

18-301 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P20911

Entry ID Method Resolution Chain Position Source
AF-P20911-F1 Predicted AlphaFoldDB

No variants for P20911

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P20911

No associated diseases with P20911

3 regional properties for P20911

Type Name Position InterPro Accession
domain Protein kinase domain 19 - 319 IPR000719
active_site Serine/threonine-protein kinase, active site 149 - 161 IPR008271
binding_site Protein kinase, ATP binding site 25 - 48 IPR017441

Functions

Description
EC Number 2.7.11.23 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
  • In the prominent nucleus of oocytes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
transcription factor TFIIK complex A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II.

3 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEGIAARGVD VRSRAKQYEK LDFLGEGQFA TVYKARDKNT DRIVAIKKIK LGHRAEANDG
70 80 90 100 110 120
INRTALREIK LLQELSHPNI IGLLDAFGHK SNISLVFDFM ETDLEVIIKD TSLVLTPAHI
130 140 150 160 170 180
KSYMLMTLQG LEYLHHLWIL HRDLKPNNLL LDENGVLKLA DFGLAKSFGS PNRIYTHQVV
190 200 210 220 230 240
TRWYRSPELL FGARMYGVGV DMWAVGCILA ELLLRVPFLP GDSDLDQLTR IFETLGTPTE
250 260 270 280 290 300
EQWPGMSSLP DYVAFKSFPG TPLHLIFIAA GDDLLELLQG LFTFNPCARC TASQALRKRY
310 320 330 340 350
FSNRPAPTPG NLLPRPNCSI EALKEQQNLN LGIKRKRTEG MDQKDIAKKL SF