P20435

PR
Gene name
RPO26 (RPB6, YPR187W, P9677.8)
Protein name
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Names
RNA polymerases I, II, and III subunit ABC2, ABC23, DNA-directed RNA polymerases I, II, and III 23 kDa polypeptide
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YPR187W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-110 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

246 structures for P20435

Entry ID Method Resolution Chain Position Source
1I3Q X-ray 310 A F 1-155 PDB
1I50 X-ray 280 A F 1-155 PDB
1I6H X-ray 330 A F 1-155 PDB
1K83 X-ray 280 A F 1-155 PDB
1NIK X-ray 410 A F 1-155 PDB
1NT9 X-ray 420 A F 1-155 PDB
1PQV X-ray 380 A F 1-155 PDB
1R5U X-ray 450 A F 1-155 PDB
1R9S X-ray 425 A F 1-155 PDB
1R9T X-ray 350 A F 1-155 PDB
1SFO X-ray 361 A F 1-155 PDB
1TWA X-ray 320 A F 1-155 PDB
1TWC X-ray 300 A F 1-155 PDB
1TWF X-ray 230 A F 1-155 PDB
1TWG X-ray 330 A F 1-155 PDB
1TWH X-ray 340 A F 1-155 PDB
1WCM X-ray 380 A F 1-155 PDB
1Y1V X-ray 380 A F 1-155 PDB
1Y1W X-ray 400 A F 1-155 PDB
1Y1Y X-ray 400 A F 1-155 PDB
1Y77 X-ray 450 A F 1-155 PDB
2B63 X-ray 380 A F 1-155 PDB
2B8K X-ray 415 A F 1-155 PDB
2E2H X-ray 395 A F 1-155 PDB
2E2I X-ray 341 A F 1-155 PDB
2E2J X-ray 350 A F 1-155 PDB
2JA5 X-ray 380 A F 1-155 PDB
2JA6 X-ray 400 A F 1-155 PDB
2JA7 X-ray 380 A F/R 1-155 PDB
2JA8 X-ray 380 A F 1-155 PDB
2NVQ X-ray 290 A F 1-155 PDB
2NVT X-ray 336 A F 1-155 PDB
2NVX X-ray 360 A F 1-155 PDB
2NVY X-ray 340 A F 1-155 PDB
2NVZ X-ray 430 A F 1-155 PDB
2R7Z X-ray 380 A F 1-155 PDB
2R92 X-ray 380 A F 1-155 PDB
2R93 X-ray 400 A F 1-155 PDB
2VUM X-ray 340 A F 1-155 PDB
2YU9 X-ray 340 A F 1-155 PDB
3CQZ X-ray 280 A F 1-155 PDB
3FKI X-ray 388 A F 1-155 PDB
3GTG X-ray 378 A F 1-155 PDB
3GTJ X-ray 342 A F 1-155 PDB
3GTK X-ray 380 A F 1-155 PDB
3GTL X-ray 338 A F 1-155 PDB
3GTM X-ray 380 A F 1-155 PDB
3GTO X-ray 400 A F 1-155 PDB
3GTP X-ray 390 A F 1-155 PDB
3GTQ X-ray 380 A F 1-155 PDB
3H3V X-ray 400 A G 1-155 PDB
3HOU X-ray 320 A F/R 1-155 PDB
3HOV X-ray 350 A F 1-155 PDB
3HOW X-ray 360 A F 1-155 PDB
3HOX X-ray 365 A F 1-155 PDB
3HOY X-ray 340 A F 1-155 PDB
3HOZ X-ray 365 A F 1-155 PDB
3I4M X-ray 370 A F 1-155 PDB
3I4N X-ray 390 A F 1-155 PDB
3J0K EM 3600 A F 72-155 PDB
3J1N EM 1600 A F 72-155 PDB
3K1F X-ray 430 A F 1-155 PDB
3K7A X-ray 380 A F 1-155 PDB
3M3Y X-ray 318 A F 1-155 PDB
3M4O X-ray 357 A F 1-155 PDB
3PO2 X-ray 330 A F 1-155 PDB
3PO3 X-ray 330 A F 1-155 PDB
3QT1 X-ray 430 A F 1-155 PDB
3RZD X-ray 330 A F 1-155 PDB
3RZO X-ray 300 A F 1-155 PDB
3S14 X-ray 285 A F 1-155 PDB
3S15 X-ray 330 A F 1-155 PDB
3S16 X-ray 324 A F 1-155 PDB
3S17 X-ray 320 A F 1-155 PDB
3S1M X-ray 313 A F 1-155 PDB
3S1N X-ray 310 A F 1-155 PDB
3S1Q X-ray 330 A F 1-155 PDB
3S1R X-ray 320 A F 1-155 PDB
3S2D X-ray 320 A F 1-155 PDB
3S2H X-ray 330 A F 1-155 PDB
4A3B X-ray 350 A F 1-155 PDB
4A3C X-ray 350 A F 1-155 PDB
4A3D X-ray 340 A F 1-155 PDB
4A3E X-ray 340 A F 1-155 PDB
4A3F X-ray 350 A F 1-155 PDB
4A3G X-ray 350 A F 1-155 PDB
4A3I X-ray 380 A F 1-155 PDB
4A3J X-ray 370 A F 1-155 PDB
4A3K X-ray 350 A F 1-155 PDB
4A3L X-ray 350 A F 1-155 PDB
4A3M X-ray 390 A F 1-155 PDB
4A93 X-ray 340 A F 1-155 PDB
4BBR X-ray 340 A F 1-155 PDB
4BBS X-ray 360 A F 1-155 PDB
4BXX X-ray 328 A F 1-155 PDB
4BXZ X-ray 480 A F 1-155 PDB
4BY1 X-ray 360 A F 1-155 PDB
4BY7 X-ray 315 A F 1-155 PDB
4C2M X-ray 280 A F/U 1-155 PDB
4C3H X-ray 327 A F 1-155 PDB
4C3I X-ray 300 A F 1-155 PDB
4C3J X-ray 335 A F 1-155 PDB
4V1M EM 660 A F 1-155 PDB
4V1N EM 780 A F 1-155 PDB
4V1O EM 970 A F 1-155 PDB
4X67 X-ray 410 A F 1-155 PDB
4X6A X-ray 396 A F 1-155 PDB
4Y52 X-ray 350 A F 1-155 PDB
4Y7N X-ray 330 A F 1-155 PDB
4YM7 X-ray 550 A AF/BF/CF/DF/EF/FF 1-155 PDB
5C3E X-ray 370 A F 1-155 PDB
5C44 X-ray 395 A F 1-155 PDB
5C4A X-ray 420 A F 1-155 PDB
5C4J X-ray 400 A F 1-155 PDB
5C4X X-ray 400 A F 1-155 PDB
5FJ8 EM 390 A F 1-155 PDB
5FJ9 EM 460 A F 1-155 PDB
5FJA EM 465 A F 1-155 PDB
5FMF EM 600 A F 72-155 PDB
5FYW EM 435 A F 1-155 PDB
5FZ5 EM 880 A F 1-155 PDB
5G5L EM 480 A F 1-155 PDB
5IP7 X-ray 352 A F 69-155 PDB
5IP9 X-ray 390 A F 69-155 PDB
5LMX EM 490 A F 1-155 PDB
5M3F EM 380 A F 1-155 PDB
5M3M EM 400 A F 1-155 PDB
5M5W EM 380 A F 1-155 PDB
5M5X EM 400 A F 1-155 PDB
5M5Y EM 400 A F 1-155 PDB
5M64 EM 460 A F 1-155 PDB
5N5Y EM 770 A F 1-155 PDB
5N5Z EM 770 A F 1-155 PDB
5N60 EM 770 A F 1-155 PDB
5N61 EM 340 A F 1-155 PDB
5OA1 EM 440 A F 1-155 PDB
5OQJ EM 470 A F 1-155 PDB
5OQM EM 580 A F 1-155 PDB
5OT2 X-ray 320 A F 1-155 PDB
5SVA EM 1530 A F 1-155 PDB
5U5Q X-ray 380 A F 1-155 PDB
5VVR EM 580 A F 1-155 PDB
5VVS EM 640 A F 1-155 PDB
5W4U X-ray 360 A F 1-155 PDB
5W51 X-ray 340 A F 1-155 PDB
5W5Y EM 380 A F 1-155 PDB
5W64 EM 420 A F 1-155 PDB
5W65 EM 430 A F 1-155 PDB
5W66 EM 390 A F 1-155 PDB
6BLO X-ray 340 A F 1-155 PDB
6BLP X-ray 320 A F 1-155 PDB
6BM2 X-ray 340 A F 1-155 PDB
6BM4 X-ray 295 A F 1-155 PDB
6BQF X-ray 335 A F 1-155 PDB
6CNB EM 410 A F 1-155 PDB
6CNC EM 410 A F 1-155 PDB
6CND EM 480 A F 1-155 PDB
6CNF EM 450 A F 1-155 PDB
6EU0 EM 400 A F 1-155 PDB
6EU1 EM 340 A F 1-155 PDB
6EU2 EM 340 A F 1-155 PDB
6EU3 EM 330 A F 1-155 PDB
6F40 EM 370 A F 1-155 PDB
6F41 EM 430 A F 1-155 PDB
6F42 EM 550 A F 1-155 PDB
6F44 EM 420 A F 1-155 PDB
6GYK EM 510 A F 2-155 PDB
6GYL EM 480 A F 1-155 PDB
6GYM EM 670 A F 1-155 PDB
6H67 EM 360 A F 1-155 PDB
6H68 EM 460 A F 1-155 PDB
6HKO EM 342 A F 1-155 PDB
6HLQ EM 318 A F 1-155 PDB
6HLR EM 318 A F 1-155 PDB
6HLS EM 321 A F 1-155 PDB
6I84 EM 440 A F 1-155 PDB
6O6C EM 310 A E 1-155 PDB
6RQH EM 370 A F 1-155 PDB
6RQL EM 290 A F 1-155 PDB
6RQT EM 400 A F 1-155 PDB
6RRD EM 310 A F 1-155 PDB
6RUI EM 270 A F 1-155 PDB
6RUO EM 350 A F 1-155 PDB
6RWE EM 300 A F 1-155 PDB
6TPS EM 354 A F 1-155 PDB
6TUT EM 325 A F 1-155 PDB
6UPX X-ray 340 A F 1-155 PDB
6UPY X-ray 340 A F 1-155 PDB
6UPZ X-ray 310 A F 1-155 PDB
6UQ0 X-ray 356 A F 1-155 PDB
6UQ1 X-ray 360 A F 1-155 PDB
6UQ2 X-ray 320 A F 1-155 PDB
6UQ3 X-ray 347 A F 1-155 PDB
7KED X-ray 360 A F 1-155 PDB
7KEE X-ray 345 A F 1-155 PDB
7KEF X-ray 389 A F 1-155 PDB
7MEI EM 354 A F/f 1-155 PDB
7MK9 EM 354 A F 1-155 PDB
7MKA EM 354 A f 1-155 PDB
7ML0 EM 300 A F 1-155 PDB
7ML1 EM 400 A F 1-155 PDB
7ML2 EM 340 A F 1-155 PDB
7ML4 EM 310 A F 1-155 PDB
7NKX EM 290 A F 1-155 PDB
7NKY EM 320 A F 1-155 PDB
7O4I EM 320 A F 1-155 PDB
7O4J EM 290 A F 1-155 PDB
7O4K EM 360 A F 1-155 PDB
7O4L EM 340 A F 1-155 PDB
7O72 EM 340 A F 1-155 PDB
7O73 EM 340 A F 1-155 PDB
7O75 EM 320 A F 1-155 PDB
7RIM X-ray 290 A F 1-155 PDB
7RIP X-ray 330 A F 1-155 PDB
7RIQ X-ray 300 A F 1-155 PDB
7RIW X-ray 320 A F 1-155 PDB
7RIX X-ray 340 A F 1-155 PDB
7RIY X-ray 370 A F 1-155 PDB
7UI9 EM 330 A F 1-155 PDB
7UIF EM 460 A F 1-155 PDB
7UIO EM 330 A AF/BF 1-155 PDB
7Z0H EM 260 A F 1-155 PDB
7Z1L EM 280 A F 1-155 PDB
7Z1M EM 340 A F 1-155 PDB
7Z1N EM 390 A F 1-155 PDB
7Z1O EM 270 A F 1-155 PDB
7Z2Z EM 307 A F 1-155 PDB
7Z30 EM 290 A F 1-155 PDB
7Z31 EM 276 A F 1-155 PDB
7ZS9 EM 310 A F 1-155 PDB
7ZSA EM 400 A F 1-155 PDB
7ZSB EM 660 A F 1-155 PDB
8BWS EM 320 A F 1-155 PDB
8CEN EM 300 A F 1-155 PDB
8CEO EM 360 A F 1-155 PDB
8JCH EM 270 A F 1-155 PDB
8K5P EM 280 A F 1-155 PDB
8TUG EM 350 A F 1-155 PDB
8TVP EM 370 A F 1-155 PDB
8TVQ EM 460 A F 1-155 PDB
8TVS EM 440 A F 1-155 PDB
8TVV EM 370 A F 1-155 PDB
8TVW EM 360 A F 1-155 PDB
8TVX EM 370 A F 1-155 PDB
8TVY EM 310 A F 1-155 PDB
AF-P20435-F1 Predicted AlphaFoldDB

1 variants for P20435

Variant ID(s) Position Change Description Diseaes Association Provenance
s16-911779 151 L>F No SGRP

No associated diseases with P20435

1 regional properties for P20435

Type Name Position InterPro Accession
conserved_site DNA-directed RNA polymerase, 14-18kDa subunit, conserved site 86 - 100 IPR020708

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RNA polymerase I complex RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
RNA polymerase II, core complex RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
RNA polymerase III complex RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
RNA polymerase I activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.

14 GO annotations of biological process

Name Definition
nucleolar large rRNA transcription by RNA polymerase I The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I.
ribosome biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
RNA-templated transcription The synthesis of an RNA transcript from an RNA template.
termination of RNA polymerase I transcription A transcription termination process that completes the production of a ribosomal RNA transcript. RNAP I termination requires binding of a terminator protein to specific sequences downstream of the transcription unit.
termination of RNA polymerase III transcription A transcription termination process that completes the production of a primary RNA polymerase II transcript. RNA polymerase III has an intrinsic ability to terminate transcription upon incorporation of at least 4 contiguous U residues.
transcription by RNA polymerase I The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter.
transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
transcription by RNA polymerase III The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter.
transcription elongation by RNA polymerase I The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I.
transcription elongation by RNA polymerase II promoter The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
transcription initiation at RNA polymerase I promoter A transcription initiation process that takes place at a RNA polymerase I gene promoter. Ribosomal RNAs (rRNA) genes are transcribed by RNA polymerase I.
transcription initiation at RNA polymerase II promoter A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II.
transcription initiation at RNA polymerase III promoter A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III.
tRNA transcription by RNA polymerase III The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9SJ96 NRPB6B DNA-directed RNA polymerases II and V subunit 6B Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSDYEEAFND GNENFEDFDV EHFSDEETYE EKPQFKDGET TDANGKTIVT GGNGPEDFQQ
70 80 90 100 110 120
HEQIRRKTLK EKAIPKDQRA TTPYMTKYER ARILGTRALQ ISMNAPVFVD LEGETDPLRI
130 140 150
AMKELAEKKI PLVIRRYLPD GSFEDWSVEE LIVDL