P20430

PR
Gene name
L
Protein name
RNA-directed RNA polymerase L
Names
Protein L, Large structural protein, Replicase, Transcriptase
Species
Tacaribe virus (strain Franze-Fernandez) (TCRV)
KEGG Pathway
vg:956595
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

892-968 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for P20430

Entry ID Method Resolution Chain Position Source

No variants for P20430

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P20430

No associated diseases with P20430

2 regional properties for P20430

Type Name Position InterPro Accession
domain RNA-directed RNA polymerase, negative-strand RNA virus 1173 - 1368 IPR007099
domain RNA endonuclease, cap-snatching 1 - 172 IPR026382

Functions

Description
EC Number
Subcellular Localization
  • Virion
  • Host cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
host cell cytoplasm The cytoplasm of a host cell.
virion component Any constituent part of a virion, a complete fully infectious extracellular virus particle.

3 GO annotations of molecular function

Name Definition
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

3 GO annotations of biological process

Name Definition
cap snatching A transcription initiation process during which a nucleotide sequence between 10 and 20 nucleotides in size is cleaved from the 5' end of host mRNAs by a viral RNA-dependent polymerase. The capped leader sequence obtained is subsequently used to prime transcription on the viral genome, which ultimately leads to the synthesis of capped, translatable viral mRNAs.
negative stranded viral RNA replication A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA).
RNA-templated viral transcription A transcription process that uses viral RNA as a template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDETVSELKD LVRKHIPNRH EFAHQKDAFL SHCHSGSLLQ EGFKLLSNLV ELESCESHAC
70 80 90 100 110 120
HLNTCQKYVD VILSDHGIPC PTLPKVIPDG FKLTGKTLIL LETFVRVNPE EFERKWKSDM
130 140 150 160 170 180
TKLLNLKQDL LRSGITLVPV VDGRTNYSNR FTPEWVVERI RWLLIEILRK SRSSAEIDIE
190 200 210 220 230 240
DQEYQRLIHS LSNVRNQSLG FENIECLKRN LLEYDDRLAK SLFVGVKGDV RESVIREELM
250 260 270 280 290 300
KLRLWYKKEV FDKNLGKFRI TNRSELLNNL IRLGKHEDNT TSDCPFCVNK FMDIIYSLTF
310 320 330 340 350 360
TALKRQDREK SNSELDQYVV CPHEKAYLGV LSICNKIKGL KVFNTRRNTL LFLDLIMVNF
370 380 390 400 410 420
LDDLFTAKPE ALDSLRRSGL ILGQMVTLVN DRALDFLEAV KLIKKKIETN VKWVENCSKI
430 440 450 460 470 480
LRRSQQDIWS QISVWARYPD LSKLISIAQT ISSDRPIMRY SAGGNFNTEC KHKTFHMMSD
490 500 510 520 530 540
AEQVEAFKIL SSVSLSLINS MKTSFSSRLL INEKEYSRYF GNVRLRECYQ QRFFLTDGLI
550 560 570 580 590 600
VILFYQKTGE RSGCYSIYTC EDGVLVEKGS FYCDPKRFFL PIFSQEVLVE MCDEMTTWLD
610 620 630 640 650 660
FNSDLMVISK EKLRLLLLSI LCAPSKRNQV FLQGLRYFLM AYSNQFHHVD LLSKLKVECM
670 680 690 700 710 720
SGSEVIVQRL AVDLFQCLLG EGVDSDPYFA RRFKYLLNVS YLCHLITKET PDRLTDQIKC
730 740 750 760 770 780
FEKFIEPKID FNCVIVNPSL NGQLTEAQEG MMLDGLDKFY SKTLKDCSDT KLPGVSNELL
790 800 810 820 830 840
SYCISLFNKG KLKVTGELKN DPFKPNITST ALDLSSNKSV VVPKLDELGN VLSVYDREKM
850 860 870 880 890 900
ISSCVSSMAE RFKTKGRYNI DPSTLDYLIL KNLTGLVSIG SKTQRDCEEL SMMFEGLTEE
910 920 930 940 950 960
QAEAFNDIKN SVQLAMVKMK DSKSGDVNLS PNQKEGRVKS STGTLEELWG PFGIMREIRT
970 980 990 1000 1010 1020
EVSLHEVKDF DPDVLASDLY KELCDVVYYS SSKPEYFLER PLEVCPLGLL LKNLTTSAYF
1030 1040 1050 1060 1070 1080
DEEYFECFKY LLIQGHYDQK LGSYEHRSRS RLGFTNEALR VKDEVRLSMR ESNSEAIADK
1090 1100 1110 1120 1130 1140
LDRSYFTNAA LRNLCFYSDD SPTEFTSISS NNGNLKFGLS YKEQVGSNRE LYVGDLNTKL
1150 1160 1170 1180 1190 1200
ITRLVEDFAE AVGSSMRYTC LSSEKEFDRA ICDMKLAVNN GDLSCSLDHS KWGPTMSPAL
1210 1220 1230 1240 1250 1260
FLTFLQFLEL RTPKERNIIN LEPVLNVLRW HLHKVIEVPV NVAEAYCTGN LKRSLGLMGC
1270 1280 1290 1300 1310 1320
GSSSVGEEFF HQFMPVQGEI PSHIMSVLDM GQGILHNMSD LYGLITEQFL NYVLDLLYDV
1330 1340 1350 1360 1370 1380
IPTSYTSSDD QVTLIKLPCA SDDNQVNDEW LEMLCFHEYL SSKLNKFVSP KSVAGTFVAE
1390 1400 1410 1420 1430 1440
FKSRFFVMGE ETPLLTQFVA AALHNVKCKT PTQLSETIDT ICDQCVANGV SVQIVSKISQ
1450 1460 1470 1480 1490 1500
RVNQLIKYSG FKETPFGAVE KQDVKDWVDG TRGYRLQRKI ESIFSDDEMT GFIRSCAKRV
1510 1520 1530 1540 1550 1560
FNDIKRGKVF EENLISLIGR DGDDALVGFL RYSSCSEQDI MRALGFRWVN LSSFGDLRLV
1570 1580 1590 1600 1610 1620
LRTKLMTSRR VLEREEVPTL IKTLQSRLSR NFTKGVKKIL AESINKSAFQ SSVASGFIGF
1630 1640 1650 1660 1670 1680
CKSIGSKCVR DGEGGFLYIK DIYTKVKPCL CEVCNMKRGV IYCRPSLEKI EKFSKPILWD
1690 1700 1710 1720 1730 1740
YFSLVLTNAC EIGEWVFSSV KEPQIPVVLS NRNLFWAVKP RIVRQLEDQL GMNHVLYSIR
1750 1760 1770 1780 1790 1800
KNYPKLFDEH LSPFMSDLQV NRTLDGRKLK FLDVCIALDL MNENLGIVSH LLKARDNSVY
1810 1820 1830 1840 1850 1860
IVKQSDCAMA HVRQSDYVDK EVGLSPQQVC YNFMVQIILS SMVNPLVMST SCLKSFFWFN
1870 1880 1890 1900 1910 1920
EVLELEDDGQ IELGELTDFT FLVRDQKISR AMFIEDIAMG YVISNLEDVR LYIDKITIGE
1930 1940 1950 1960 1970 1980
QPLAPGRHIN DLLDLLGNFD DHEDCDLRFL IQVEHSRTST KYRFKRKMTY SFSVTCVSKV
1990 2000 2010 2020 2030 2040
IDLKEASVEL QVVDVTQSVS GSGGSHLLLD GVSMIAGLPI FTGQGTFNMA SLMMDADLVE
2050 2060 2070 2080 2090 2100
TNDNLILTDV RFSFGGFLSE LSDKYAYTLN GPVDQGEPLV LRDGHFFMGT EKVSTYRVEL
2110 2120 2130 2140 2150 2160
TGDIIVKAIG ALDDPEDVNA LLNQLWPYLK STAQVMLFQQ EDFVLVYDLH RSGLIRSLEL
2170 2180 2190 2200
IGDWVEFVNF KVAYSKSLKD LVVSDNQGSL RLRGIMCRPL ARRNTVEDIE