AiPD: Autoinhibited Protein Database

P20290

Gene name	BTF3 (NACB, OK/SW-cl.8)
Protein name	Transcription factor BTF3
Names	Nascent polypeptide-associated complex subunit beta, NAC-beta, RNA polymerase B transcription factor 3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:689
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

37-112 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

37-112 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

5 structures for P20290

Entry ID	Method	Resolution	Chain	Position	Source
3LKX	X-ray	250 A	A	97-162	PDB
3MCB	X-ray	190 A	B	97-154	PDB
7QWQ	EM	283 A	u	45-206	PDB
7QWR	EM	290 A	u	45-206	PDB
AF-P20290-F1	Predicted				AlphaFoldDB

133 variants for P20290

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	2	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755340655 CA360109859	3	R>L		No	ClinGen ExAC TOPMed gnomAD
CA3303150 rs755340655	3	R>P		No	ClinGen ExAC TOPMed gnomAD
CA360109854 rs755340655	3	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA360109873 rs868180059	4	T>I		No	ClinGen gnomAD
CA121246183 rs868180059	4	T>K		No	ClinGen gnomAD
rs1277498805 CA360109894	5	G>D		No	ClinGen gnomAD
CA360109932 rs1235897517	7	P>L		No	ClinGen gnomAD
rs1235897517 CA360109931	7	P>R		No	ClinGen gnomAD
CA360109924 rs1580356583	7	P>S		No	ClinGen Ensembl
CA3303152 rs752955577	8	A>V		No	ClinGen ExAC TOPMed gnomAD
rs916583663 CA121246198	9	Q>H		No	ClinGen TOPMed
CA121246192 rs866966564	9	Q>K		No	ClinGen Ensembl
rs758924385 CA3303153	10	A>D		No	ClinGen ExAC TOPMed gnomAD
rs758924385 CA360110024	10	A>V		No	ClinGen ExAC TOPMed gnomAD
CA360110042 rs1476937438	11	D>A		No	ClinGen gnomAD
rs375502008 CA3303154	11	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA360110064 rs1424744274	12	S>P		No	ClinGen gnomAD
CA121246212 rs746927933	13	R>P		No	ClinGen TOPMed gnomAD
rs1415192584 CA360110088	13	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	14	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA121246227 rs955444008	16	G>D		No	ClinGen Ensembl
CA360110161 rs370228487	17	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs370228487 CA3303155	17	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	19	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1414613781 CA360110258	21	G>C		No	ClinGen gnomAD
CA360110266 rs1337997401	21	G>D		No	ClinGen gnomAD
CA360110283 rs1274561202	22	C>R		No	ClinGen gnomAD
CA121246229 rs906717629	22	C>Y		No	ClinGen TOPMed
CA3303156 rs757317946	23	P>S		No	ClinGen ExAC TOPMed gnomAD
rs757317946 CA3303157	23	P>T		No	ClinGen ExAC TOPMed gnomAD
rs746130133 CA3303158	24	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1398411592 CA360110340	25	G>C		No	ClinGen TOPMed gnomAD
rs1036457953 CA121246261	25	G>V		No	ClinGen TOPMed
CA360110352 rs1386843777	26	E>Q		No	ClinGen Ensembl
CA360110449 rs1255738287	32	P>L		No	ClinGen gnomAD
rs1309824236 CA360110446	32	P>S		No	ClinGen TOPMed
CA360110453 rs1316799707	33	P>L		No	ClinGen gnomAD
CA360110460 rs1449744185	34	P>L		No	ClinGen gnomAD
rs911238120 CA121246263	34	P>S		No	ClinGen TOPMed gnomAD
rs1197916306 CA360110466	35	R>L		No	ClinGen gnomAD
CA121246265 rs896915700	36	G>D		No	ClinGen TOPMed
rs1478880983 CA360110481	38	T>I		No	ClinGen gnomAD
rs1201910459 CA360110487	39	R>*		No	ClinGen gnomAD
CA360110506 rs1421701678	40	G>E		No	ClinGen TOPMed gnomAD
CA121246266 rs1141021	41	Q>E		No	ClinGen Ensembl
CA3303159 rs769856280	42	E>Q		No	ClinGen ExAC gnomAD
rs758761066 CA3303172	45	M>I		No	ClinGen ExAC
CA360110662 rs1392031938	49	I>V		No	ClinGen gnomAD
rs764646227 CA3303173	51	N>K		No	ClinGen ExAC
CA3303174 rs752042689	52	Q>H		No	ClinGen ExAC gnomAD
CA121246657 rs949816934	56	A>T		No	ClinGen Ensembl
rs1252585619 CA360110718	56	A>V		No	ClinGen TOPMed
rs757719063 CA3303175	57	K>E		No	ClinGen ExAC gnomAD
rs750408507 CA121246703	60	A>E		No	ClinGen ExAC gnomAD
CA3303177 rs750408507	60	A>G		No	ClinGen ExAC gnomAD
rs1482433932 CA360110740	60	A>S		No	ClinGen TOPMed
rs1338243858 CA360110759	63	R>C		No	ClinGen gnomAD
CA121246705 rs926939545	65	G>S		No	ClinGen Ensembl
CA3303240 rs766853542	71	R>H		No	ClinGen ExAC gnomAD
rs1192476330 CA360111316	72	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA360111357 rs1332017959	75	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA360111360 rs1379009626	75	K>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1162650979 CA360111371	76	V>M		No	ClinGen gnomAD
TCGA novel	78	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	79	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA121249140 rs765616938	80	T>A		No	ClinGen ExAC TOPMed gnomAD
CA3303243 rs765616938	80	T>P		No	ClinGen ExAC TOPMed gnomAD
CA121249152 rs982914280	83	A>V		No	ClinGen TOPMed
rs11556916 CA121249156	84	D>Y		No	ClinGen Ensembl
CA3303245 rs146671283	86	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA3303246 rs767250561	89	Q>R		No	ClinGen ExAC gnomAD
CA360111556 rs1236701690	92	L>F		No	ClinGen TOPMed gnomAD
CA360111567 rs1216363290	94	K>E		No	ClinGen gnomAD
rs377307371 CA3303248	97	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs377307371 CA3303249	97	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA3303250 rs376732614	99	N>S		No	ClinGen ESP ExAC gnomAD
TCGA novel	100	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1215511257 CA360111617	101	S>C		No	ClinGen gnomAD
rs1486582188 CA360111630	103	I>S		No	ClinGen gnomAD
rs754868948 CA3303270	107	N>S		No	ClinGen ExAC gnomAD
rs996682498 CA121249436	108	M>V		No	ClinGen TOPMed gnomAD
rs778415639 CA3303271	111	N>D		No	ClinGen ExAC gnomAD
CA360111703 rs1280571469	112	Q>E		No	ClinGen gnomAD
CA121249449 rs1050429962	113	G>R		No	ClinGen gnomAD
CA3303273 rs757993865	114	T>A		No	ClinGen ExAC TOPMed gnomAD
CA3303274 rs757993865	114	T>S		No	ClinGen ExAC TOPMed gnomAD
CA3303275 rs747392162	115	V>A		No	ClinGen ExAC gnomAD
CA360111722 rs747392162	115	V>G		No	ClinGen ExAC gnomAD
CA360111724 rs1256094316	116	I>V		No	ClinGen gnomAD
rs878981435 CA121249474	121	P>L		No	ClinGen Ensembl
rs966602011 CA121249478	122	K>R		No	ClinGen Ensembl
TCGA novel	123	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1182433703 CA360111782	124	Q>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA360111801 rs1367160041	127	L>V		No	ClinGen TOPMed
CA360111811 rs1234453441	129	A>T		No	ClinGen gnomAD
CA360111814 rs1161723411	129	A>V		No	ClinGen gnomAD
CA3303278 rs746411488	133	T>P		No	ClinGen ExAC gnomAD
CA121249508 rs41271745	140	T>A		No	ClinGen Ensembl
rs1409951460 CA360111889	140	T>I		No	ClinGen gnomAD
TCGA novel	141	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1422354682 CA360111926	146	M>V		No	ClinGen TOPMed
CA121249539 rs201235182	150	I>T		No	ClinGen 1000Genomes TOPMed
CA121249526 rs143150590	150	I>V		No	ClinGen ESP TOPMed gnomAD
rs1282265190 CA360111985	154	L>P		No	ClinGen gnomAD
CA3303283 rs372460087	156	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA360112009 rs1207304383	158	S>N		No	ClinGen TOPMed
CA360112012 rs1318635089	158	S>R		No	ClinGen TOPMed
CA3303285 rs766190108	161	S>G		No	ClinGen ExAC gnomAD
CA360112031 rs1580358844	161	S>R		No	ClinGen Ensembl
COSM177818 CA3303287 rs186931485	167	E>K	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA121250343 rs2703643	174	V>G		No	ClinGen Ensembl
rs772223535 CA3303307	174	V>M		No	ClinGen ExAC gnomAD
rs1311504384 CA360112184	175	D>V		No	ClinGen TOPMed
TCGA novel	178	A>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	178	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs12332640 CA121250346	178	A>T		No	ClinGen Ensembl
CA3303309 rs759324851	179	P>S		No	ClinGen ExAC gnomAD
rs773022738 CA121250350	180	L>F		No	ClinGen TOPMed
CA360112253 rs1163491446	181	A>G		No	ClinGen gnomAD
rs765146287 CA3303310	182	T>S		No	ClinGen ExAC gnomAD
rs1426913618 CA360112269	183	G>A		No	ClinGen TOPMed gnomAD
rs1300448238 CA360112265	183	G>R		No	ClinGen TOPMed
CA3303313 rs760319904	185	D>E		No	ClinGen ExAC TOPMed gnomAD
CA360112303 rs1383736852	186	D>E		No	ClinGen gnomAD
CA121250392 rs991534070	186	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA360112357 rs1369153040	191	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs763692757 CA3303315	192	D>N		No	ClinGen ExAC gnomAD
CA360112473 rs1176430427	195	E>G		No	ClinGen gnomAD
CA360112486 rs1464051814	196	N>S		No	ClinGen gnomAD
TCGA novel	201	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs34963032 CA121250962	203	N>K		No	ClinGen Ensembl
rs1310848022 CA360112624	206	N>S		No	ClinGen gnomAD

No associated diseases with P20290

1 regional properties for P20290

Type	Name	Position	InterPro Accession
domain	Major facilitator superfamily domain	80 - 495	IPR020846

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus	The heterodimer with NACA is cytoplasmic
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nascent polypeptide-associated complex	A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
polysomal ribosome	A ribosome bound to mRNA that forms part of a polysome.

1 GO annotations of molecular function

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.

2 GO annotations of biological process

Name	Definition
negative regulation of protein localization to endoplasmic reticulum	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to endoplasmic reticulum.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5M8V0	btf3l4	Transcription factor BTF3 homolog 4	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MRRTGAPAQA	DSRGRGRARG	GCPGGEATLS	QPPPRGGTRG	QEPQMKETIM	NQEKLAKLQA
70	80	90	100	110	120
QVRIGGKGTA	RRKKKVVHRT	ATADDKKLQF	SLKKLGVNNI	SGIEEVNMFT	NQGTVIHFNN
130	140	150	160	170	180
PKVQASLAAN	TFTITGHAET	KQLTEMLPSI	LNQLGADSLT	SLRRLAEALP	KQSVDGKAPL
190	200
ATGEDDDDEV	PDLVENFDEA	SKNEAN