P19893

PR
Gene name
UL122
Protein name
Viral transcription factor IE2
Names
IE2, Protein UL122
Species
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

174-355 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P19893

Entry ID Method Resolution Chain Position Source
6K5R NMR - B 195-206 PDB
6K5T NMR - B 195-206 PDB

No variants for P19893

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P19893

No associated diseases with P19893

1 regional properties for P19893

Type Name Position InterPro Accession
domain Herpesvirus intermediate/early protein 2/3 383 - 543 IPR005028

Functions

Description
EC Number
Subcellular Localization
  • Host nucleus
  • Colocalizes with host PML-associated nuclear bodies
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
metal ion binding Binding to a metal ion.

5 GO annotations of biological process

Name Definition
bidirectional double-stranded viral DNA replication A viral DNA replication process where replication occurs in both directions from the starting point. This creates two replication forks, moving in opposite directions.
DNA-templated viral transcription A transcription process that uses a viral DNA as a template.
modulation by virus of host G0/G1 transition checkpoint Any viral process that modulates the frequency, rate or extent of the host cell G0/G1 transition checkpoint.
modulation by virus of host G1/S transition checkpoint Any viral process that modulates the frequency, rate or extent of the host cell G1/S transition checkpoint.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MESSAKRKMD PDNPDEGPSS KVPRPETPVT KATTFLQTML RKEVNSQLSL GDPLFPELAE
70 80 90 100 110 120
ESLKTFEQVT EDCNENPEKD VLAELGDILA QAVNHAGIDS SSTGPTLTTH SCSVSSAPLN
130 140 150 160 170 180
KPTPTSVAVT NTPLPGASAT PELSPRKKPR KTTRPFKVII KPPVPPAPIM LPLIKQEDIK
190 200 210 220 230 240
PEPDFTIQYR NKIIDTAGCI VISDSEEEQG EEVETRGATA SSPSTGSGTP RVTSPTHPLS
250 260 270 280 290 300
QMNHPPLPDP LGRPDEDSSS SSSSSCSSAS DSESESEEMK CSSGGGASVT SSHHGRGGFG
310 320 330 340 350 360
GAASSSLLSC GHQSSGGAST GPRKKKSKRI SELDNEKVRN IMKDKNTPFC TPNVQTRRGR
370 380 390 400 410 420
VKIDEVSRMF RNTNRSLEYK NLPFTIPSMH QVLDEAIKAC KTMQVNNKGI QIIYTRNHEV
430 440 450 460 470 480
KSEVDAVRCR LGTMCNLALS TPFLMEHTMP VTHPPEVAQR TADACNEGVK AAWSLKELHT
490 500 510 520 530 540
HQLCPRSSDY RNMIIHAATP VDLLGALNLC LPLMQKFPKQ VMVRIFSTNQ GGFMLPIYET
550 560 570
AAKAYAVGQF EQPTETPPED LDTLSLAIEA AIQDLRNKSQ