P19576

PR
Gene name
malE (STM4229)
Protein name
Maltose/maltodextrin-binding periplasmic protein
Names
MMBP, Maltodextrin-binding protein, Maltose-binding protein, MBP
Species
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
KEGG Pathway
stm:STM4229
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

297-373 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for P19576

Entry ID Method Resolution Chain Position Source
3JYR X-ray 175 A A 1-396 PDB
6L0Z X-ray 160 A A 27-396 PDB
6L3E X-ray 160 A A 27-396 PDB
7FFT X-ray 160 A A 27-396 PDB
7FFW X-ray 160 A A 27-396 PDB
AF-P19576-F1 Predicted AlphaFoldDB

No variants for P19576

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P19576

No associated diseases with P19576

1 regional properties for P19576

Type Name Position InterPro Accession
conserved_site Solute-binding family 1, conserved site 133 - 150 IPR006061

Functions

Description
EC Number
Subcellular Localization
  • Periplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP.
periplasmic space The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

2 GO annotations of molecular function

Name Definition
carbohydrate transmembrane transporter activity Enables the transfer of carbohydrate from one side of a membrane to the other.
maltose binding Binding to maltose.

2 GO annotations of biological process

Name Definition
maltodextrin transmembrane transport The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, across a membrane.
maltose transport The directed movement of maltose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the catabolism of glycogen and starch.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKIKTGVGIL ALSALTTMMI SAPALAKIEE GKLVIWINGD KGYNGLAEVG KKFEQDTGIK
70 80 90 100 110 120
VTVEHPDKLE EKFPQVAATG DGPDIIFWAH DRFGGYAQSG LLAEVTPDKA FQDKLYPFTW
130 140 150 160 170 180
DAVRYNGKLI AYPIAVEALS LIYNKDLVPN PPKTWEEIPA LDKELKVKGK SAIMFNLQEP
190 200 210 220 230 240
YFTWPLIAAD GGYAFKFENG KYDVKDVGVD NAGAKAGLTF LIDMIKNKNM SADTDYSIAE
250 260 270 280 290 300
AAFNKGETAM TINGPWAWSN IDKSKVNYGV TLLPTFKGKP SKPFVGVLSA GINAASPNKE
310 320 330 340 350 360
LAKEFLENYL LTDQGLEAVN KDKPLGAVAL KSFQEQLAKD PRIAATMDNA QKGEIMPNIP
370 380 390
QMSAFWYAVR TAVINAASGR QTVDAALKDA QSRITK