P19358

PR
Gene name
SAM2 (ETH2, YDR502C, D9719.8)
Protein name
S-adenosylmethionine synthase 2
Names
AdoMet synthase 2, Methionine adenosyltransferase 2, MAT 2
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDR502C
EC number
2.5.1.6: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P19358

Entry ID Method Resolution Chain Position Source
AF-P19358-F1 Predicted AlphaFoldDB

2 variants for P19358

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-1453491 322 D>E No SGRP
s04-1453490 323 T>S No SGRP

No associated diseases with P19358

5 regional properties for P19358

Type Name Position InterPro Accession
domain S-adenosylmethionine synthetase, N-terminal 7 - 104 IPR022628
domain S-adenosylmethionine synthetase, central domain 119 - 239 IPR022629
domain S-adenosylmethionine synthetase, C-terminal 241 - 378 IPR022630
conserved_site S-adenosylmethionine synthetase, conserved site 120 - 130 IPR022631-1
conserved_site S-adenosylmethionine synthetase, conserved site 267 - 275 IPR022631-2

Functions

Description
EC Number 2.5.1.6 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
methionine adenosyltransferase activity Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.

3 GO annotations of biological process

Name Definition
methionine metabolic process The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
S-adenosylmethionine biosynthetic process The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKSKTFLFT SESVGEGHPD KICDQVSDAI LDACLEQDPF SKVACETAAK TGMIMVFGEI
70 80 90 100 110 120
TTKARLDYQQ IVRDTIKKIG YDDSAKGFDY KTCNVLVAIE QQSPDIAQGL HYEKSLEDLG
130 140 150 160 170 180
AGDQGIMFGY ATDETPEGLP LTILLAHKLN MAMADARRDG SLPWLRPDTK TQVTVEYEDD
190 200 210 220 230 240
NGRWVPKRID TVVISAQHAD EISTADLRTQ LQKDIVEKVI PKDMLDENTK YFIQPSGRFV
250 260 270 280 290 300
IGGPQGDAGL TGRKIIVDAY GGASSVGGGA FSGKDYSKVD RSAAYAARWV AKSLVAAGLC
310 320 330 340 350 360
KRVQVQFSYA IGIAEPLSLH VDTYGTATKS DDEIIEIIKK NFDLRPGVLV KELDLARPIY
370 380
LPTASYGHFT NQEYSWEKPK KLEF