P18819
Gene name |
gdhA (AN4376) |
Protein name |
NADP-specific glutamate dehydrogenase |
Names |
NADP-GDH, NADP-dependent glutamate dehydrogenase |
Species |
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
KEGG Pathway |
ani:AN4376.2 |
EC number |
1.4.1.4: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P18819
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P18819-F1 | Predicted | AlphaFoldDB |
No variants for P18819
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P18819 | |||||
No associated diseases with P18819
4 regional properties for P18819
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, C-terminal | 188 - 456 | IPR006096 |
| domain | Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, dimerisation domain | 43 - 170 | IPR006097 |
| active_site | Leu/Phe/Val dehydrogenases active site | 108 - 121 | IPR033524 |
| domain | NAD(P) binding domain of glutamate dehydrogenase | 181 - 457 | IPR033922 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.4.1.4 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| glutamate dehydrogenase (NADP+) activity | Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to farnesol | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus. |
| glutamate biosynthetic process | The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSNLPVEPEF | EQAYKELAST | LENSTLFEQH | PEYRRALQVV | SVPERVIQFR | VVWENDKGEV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QINRGYRVQF | NSALGPYKGG | LRFHPSVNLS | ILKFLGFEQI | FKNALTGLNM | GGGKGGSDFD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PKGKSDSEIR | RFCTAFMTEL | CKHIGADTDV | PAGDIGVTGR | EVGFLFGQYR | RIRNQWEGVL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TGKGGSWGGS | LIRPEATGYG | VVYYVEHMIK | HVTGGKESFA | GKRVAISGSG | NVAQYAALKV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IELGGSVVSL | SDSKGSLIVK | DESASFTPEE | IALIADLKVA | RKQLSELATS | SAFAGKFTYI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PDARPWTNIP | GKFEVALPSA | TQNEVSGEEA | EHLIKSGVRY | IAEGSNMGCT | QAAIDIFEAH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RNANPGDAIW | YAPGKAANAG | GVAVSGLEMA | QNSARLSWTS | EEVDARLKGI | MEDCFKNGLE |
| 430 | 440 | 450 | |||
| TAQKFATPAK | GVLPSLVTGS | NIAGFTKVAE | AMKDQGDWW |