Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P18755
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P18755-F1 | Predicted | AlphaFoldDB |
No variants for P18755
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P18755 | |||||
No associated diseases with P18755
No regional properties for P18755
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P18755 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of endothelial cell migration | Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. |
| positive regulation of erythrocyte differentiation | Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation. |
| regulation of angiogenesis | Any process that modulates the frequency, rate or extent of angiogenesis. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKAALDLKPT | LSIKTEKEYE | AYSCSDMECA | DVPLLTPSSK | EMMSQALRAT | FSRFTKEQQR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LGIPIDPREW | TDMHVREWVS | WAVNEFTLKG | VDFQKFCMSG | AALCALGKEC | FLELAPDFVG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DILWEHLEIL | QKDSKQYQTS | EITPAYPESR | YTSDYFISYG | IEHAQCVPPS | EFSEPSFITE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SYQTLHPISS | EELLSLKYEN | DYPLGLLRDP | LQPESLQGDY | FTIKQEVVTP | DNMCLGRISR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GKLGGQESFE | SIESHDSCDR | LTQSWSSQSS | YNSLQRVPSY | DSFDSEDYPP | AMPSHKSKGT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FKDYVRDRAE | LNKDKPVIPA | AALAGYTGSG | PIQLWQFLLE | LLTDKSCQSF | ISWTGDGWEF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KLSDPDEVAR | RWGKRKNKPK | MNYEKLSRGL | RYYYDKNIIH | KTAGKRYVYR | FVCDLQSLLG |
| 430 | |||||
| YVPEELHAML | DVKPDTDE |