P18645
Gene name |
Gale |
Protein name |
UDP-glucose 4-epimerase |
Names |
Galactowaldenase, UDP-N-acetylglucosamine 4-epimerase, UDP-GlcNAc 4-epimerase, UDP-galactosamine 4-epimerase, UDP-GalNAc 4-epimerase, UDP-galactose 4-epimerase |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
|
EC number |
5.1.3.2: Acting on carbohydrates and derivatives |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P18645
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P18645-F1 | Predicted | AlphaFoldDB |
No variants for P18645
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P18645 | |||||
No associated diseases with P18645
1 regional properties for P18645
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | NAD(P)-binding domain | 6 - 331 | IPR016040 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.1.3.2 | Acting on carbohydrates and derivatives |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| UDP-glucose 4-epimerase activity | Catalysis of the reaction: UDP-glucose = UDP-galactose. |
| UDP-N-acetylglucosamine 4-epimerase activity | Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| galactose catabolic process | The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose. |
| galactose catabolic process via UDP-galactose | The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose. |
| galactose metabolic process | The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEEKVLVTGG | AGYIGSHTVL | ELLEAGYSPV | VIDNFHNSIR | GEDSMPESLR | RVQELTGRSV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EFEEMDILDQ | AALQHLFKKH | NFKAVIHFAG | LKAVGESVQK | PLDYYRVNLT | GTIQLLEIMR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AMGVKSLVFS | SSATVYGKPV | PASGRGPPHR | GCTKPYGKSK | FFIEEMIQDL | CRADTAWNAV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LLRYFIPIGA | HRSARIGEDP | QGIPNNLMPY | VSQVAIGRRE | ALNVFGDDYA | TEDGTGVRDY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IHVVDLAKGH | IAALKKLKEQ | CGCRIYNLGT | GTGYSVLQMV | QAMEKASGKK | IPYKVVARRE |
| 310 | 320 | 330 | 340 | ||
| GDVAACYANP | SLAHEELGWT | AALGLDRMCE | DLWRWQKQNP | SGLGAHG |