P18616

PR
Gene name
NRPB1
Protein name
DNA-directed RNA polymerase II subunit RPB1
Names
DNA polymerase II subunit B1, DNA-directed RNA polymerase II largest subunit, DNA-directed RNA polymerase II subunit 1
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G35800
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1472-1839 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P18616

Entry ID Method Resolution Chain Position Source
AF-P18616-F1 Predicted AlphaFoldDB

27 variants for P18616

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00554139 137 I>V No 1000Genomes
ENSVATH06830934 159 H>R No 1000Genomes
tmp_4_16967112_T_C 167 K>R No 1000Genomes
tmp_4_16967104_C_A 170 G>C No 1000Genomes
ENSVATH12417270 583 R>C No 1000Genomes
ENSVATH12417231 928 T>S No 1000Genomes
ENSVATH02962207 942 R>Q No 1000Genomes
tmp_4_16963723_C_T 1044 S>N No 1000Genomes
ENSVATH14342379 1182 I>V No 1000Genomes
ENSVATH14342378 1208 P>L No 1000Genomes
tmp_4_16963061_C_T 1265 G>S No 1000Genomes
ENSVATH14342377 1312 R>G No 1000Genomes
tmp_4_16962910_T_A 1315 E>V No 1000Genomes
tmp_4_16962418_A_T 1479 L>H No 1000Genomes
tmp_4_16962341_C_T 1505 G>S No 1000Genomes
ENSVATH06830919 1540 S>P No 1000Genomes
ENSVATH14342353 1572 Y>F No 1000Genomes
tmp_4_16961986_G_A 1623 P>L No 1000Genomes
ENSVATH00554121 1629 S>C No 1000Genomes
tmp_4_16961925_G_C 1643 S>R No 1000Genomes
ENSVATH02962202 1689 P>L No 1000Genomes
tmp_4_16961663_C_T 1731 A>T No 1000Genomes
ENSVATH14342349 1763 S>T No 1000Genomes
tmp_4_16961276_T_G 1787 S>R No 1000Genomes
tmp_4_16961156_C_G 1827 G>R No 1000Genomes
ENSVATH12417192 1837 G>S No 1000Genomes
tmp_4_16961119_G_A 1839 P>L No 1000Genomes

No associated diseases with P18616

17 regional properties for P18616

Type Name Position InterPro Accession
repeat RNA polymerase II, heptapeptide repeat, eukaryotic 1552 - 1565 IPR000684-1
repeat RNA polymerase II, heptapeptide repeat, eukaryotic 1566 - 1579 IPR000684-2
repeat RNA polymerase II, heptapeptide repeat, eukaryotic 1580 - 1593 IPR000684-3
repeat RNA polymerase II, heptapeptide repeat, eukaryotic 1594 - 1635 IPR000684-4
repeat RNA polymerase II, heptapeptide repeat, eukaryotic 1636 - 1649 IPR000684-5
repeat RNA polymerase II, heptapeptide repeat, eukaryotic 1650 - 1691 IPR000684-6
repeat RNA polymerase II, heptapeptide repeat, eukaryotic 1692 - 1719 IPR000684-7
repeat RNA polymerase II, heptapeptide repeat, eukaryotic 1721 - 1733 IPR000684-8
repeat RNA polymerase II, heptapeptide repeat, eukaryotic 1752 - 1780 IPR000684-9
domain RNA polymerase, alpha subunit 353 - 521 IPR000722
domain RNA polymerase, N-terminal 243 - 549 IPR006592
domain RNA polymerase Rpb1, domain 3 525 - 688 IPR007066
domain RNA polymerase Rpb1, domain 7 1161 - 1295 IPR007073
domain RNA polymerase Rpb1, domain 6 892 - 1076 IPR007075
domain RNA polymerase Rpb1, domain 1 14 - 351 IPR007080
domain RNA polymerase Rpb1, domain 5 826 - 1416 IPR007081
domain RNA polymerase Rpb1, domain 4 719 - 819 IPR007083

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
  • Nucleus
  • Peri-nucleolar
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
plant-type vacuole A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana.
plasmodesma A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
RNA polymerase II, core complex RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDTRFPFSPA EVSKVRVVQF GILSPDEIRQ MSVIHVEHSE TTEKGKPKVG GLSDTRLGTI
70 80 90 100 110 120
DRKVKCETCM ANMAECPGHF GYLELAKPMY HVGFMKTVLS IMRCVCFNCS KILADEEEHK
130 140 150 160 170 180
FKQAMKIKNP KNRLKKILDA CKNKTKCDGG DDIDDVQSHS TDEPVKKSRG GCGAQQPKLT
190 200 210 220 230 240
IEGMKMIAEY KIQRKKNDEP DQLPEPAERK QTLGADRVLS VLKRISDADC QLLGFNPKFA
250 260 270 280 290 300
RPDWMILEVL PIPPPPVRPS VMMDATSRSE DDLTHQLAMI IRHNENLKRQ EKNGAPAHII
310 320 330 340 350 360
SEFTQLLQFH IATYFDNELP GQPRATQKSG RPIKSICSRL KAKEGRIRGN LMGKRVDFSA
370 380 390 400 410 420
RTVITPDPTI NIDELGVPWS IALNLTYPET VTPYNIERLK ELVDYGPHPP PGKTGAKYII
430 440 450 460 470 480
RDDGQRLDLR YLKKSSDQHL ELGYKVERHL QDGDFVLFNR QPSLHKMSIM GHRIRIMPYS
490 500 510 520 530 540
TFRLNLSVTS PYNADFDGDE MNMHVPQSFE TRAEVLELMM VPKCIVSPQA NRPVMGIVQD
550 560 570 580 590 600
TLLGCRKITK RDTFIEKDVF MNTLMWWEDF DGKVPAPAIL KPRPLWTGKQ VFNLIIPKQI
610 620 630 640 650 660
NLLRYSAWHA DTETGFITPG DTQVRIERGE LLAGTLCKKT LGTSNGSLVH VIWEEVGPDA
670 680 690 700 710 720
ARKFLGHTQW LVNYWLLQNG FTIGIGDTIA DSSTMEKINE TISNAKTAVK DLIRQFQGKE
730 740 750 760 770 780
LDPEPGRTMR DTFENRVNQV LNKARDDAGS SAQKSLAETN NLKAMVTAGS KGSFINISQM
790 800 810 820 830 840
TACVGQQNVE GKRIPFGFDG RTLPHFTKDD YGPESRGFVE NSYLRGLTPQ EFFFHAMGGR
850 860 870 880 890 900
EGLIDTAVKT SETGYIQRRL VKAMEDIMVK YDGTVRNSLG DVIQFLYGED GMDAVWIESQ
910 920 930 940 950 960
KLDSLKMKKS EFDRTFKYEI DDENWNPTYL SDEHLEDLKG IRELRDVFDA EYSKLETDRF
970 980 990 1000 1010 1020
QLGTEIATNG DSTWPLPVNI KRHIWNAQKT FKIDLRKISD MHPVEIVDAV DKLQERLLVV
1030 1040 1050 1060 1070 1080
PGDDALSVEA QKNATLFFNI LLRSTLASKR VLEEYKLSRE AFEWVIGEIE SRFLQSLVAP
1090 1100 1110 1120 1130 1140
GEMIGCVAAQ SIGEPATQMT LNTFHYAGVS AKNVTLGVPR LREIINVAKR IKTPSLSVYL
1150 1160 1170 1180 1190 1200
TPEASKSKEG AKTVQCALEY TTLRSVTQAT EVWYDPDPMS TIIEEDFEFV RSYYEMPDED
1210 1220 1230 1240 1250 1260
VSPDKISPWL LRIELNREMM VDKKLSMADI AEKINLEFDD DLTCIFNDDN AQKLILRIRI
1270 1280 1290 1300 1310 1320
MNDEGPKGEL QDESAEDDVF LKKIESNMLT EMALRGIPDI NKVFIKQVRK SRFDEEGGFK
1330 1340 1350 1360 1370 1380
TSEEWMLDTE GVNLLAVMCH EDVDPKRTTS NHLIEIIEVL GIEAVRRALL DELRVVISFD
1390 1400 1410 1420 1430 1440
GSYVNYRHLA ILCDTMTYRG HLMAITRHGI NRNDTGPLMR CSFEETVDIL LDAAAYAETD
1450 1460 1470 1480 1490 1500
CLRGVTENIM LGQLAPIGTG DCELYLNDEM LKNAIELQLP SYMDGLEFGM TPARSPVSGT
1510 1520 1530 1540 1550 1560
PYHEGMMSPN YLLSPNMRLS PMSDAQFSPY VGGMAFSPSS SPGYSPSSPG YSPTSPGYSP
1570 1580 1590 1600 1610 1620
TSPGYSPTSP GYSPTSPTYS PSSPGYSPTS PAYSPTSPSY SPTSPSYSPT SPSYSPTSPS
1630 1640 1650 1660 1670 1680
YSPTSPSYSP TSPSYSPTSP AYSPTSPAYS PTSPAYSPTS PSYSPTSPSY SPTSPSYSPT
1690 1700 1710 1720 1730 1740
SPSYSPTSPS YSPTSPAYSP TSPGYSPTSP SYSPTSPSYG PTSPSYNPQS AKYSPSIAYS
1750 1760 1770 1780 1790 1800
PSNARLSPAS PYSPTSPNYS PTSPSYSPTS PSYSPSSPTY SPSSPYSSGA SPDYSPSAGY
1810 1820 1830
SPTLPGYSPS STGQYTPHEG DKKDKTGKKD ASKDDKGNP