P18333

PR
Gene name
sigA
Protein name
RNA polymerase sigma factor SigA
Names
Sigma-66, Sigma-70, Sigma-A
Species
Chlamydia trachomatis (strain D/UW-3/Cx)
KEGG Pathway
ctr:CT_615
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-323 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P18333

Entry ID Method Resolution Chain Position Source
AF-P18333-F1 Predicted AlphaFoldDB

No variants for P18333

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P18333

No associated diseases with P18333

4 regional properties for P18333

Type Name Position InterPro Accession
domain Helicase, C-terminal 235 - 396 IPR001650
domain DEAD/DEAH box helicase domain 48 - 211 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 42 - 239 IPR014001
domain RNA helicase, DEAD-box type, Q motif 23 - 51 IPR014014

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
sigma factor activity Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.

1 GO annotations of biological process

Name Definition
DNA-templated transcription initiation The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRMDTLDSQA AEAAQEEEIQ RKLEELVTLA KDQGFITYEE INEILPPSFD TPEQIDQVLI
70 80 90 100 110 120
FLAGMDVQVL NQADVERQKE RKKEAKELEG LAKRSEGTPD DPVRMYLKEM GTVPLLTREE
130 140 150 160 170 180
EVEISKRIEK AQVQIERIIL RFRYSTKEAV SIAQYLINGK ERFDKIVSEK EVEDKTHFLN
190 200 210 220 230 240
LLPKLISLLK EEDAYLEERL LALKDPALSK PDQARLNDEL EKCRIRTQAY LRCFHCRHNV
250 260 270 280 290 300
TEDFGEVVFK AYDSFLQLEQ QINDLKARAE RNKFAAAKLA AARRKLHKRE VAAGRTLEEF
310 320 330 340 350 360
KKDVRMLQRW MDKSQEAKKE MVESNLRLVI SIAKKYTNRG LSFLDLIQEG NMGLMKAVEK
370 380 390 400 410 420
FEYRRGYKFS TYATWWIRQA VTRAIADQAR TIRIPVHMIE TINKVLRGAK KLMMETGKEP
430 440 450 460 470 480
TPEELGEELG FTPDRVREIY KIAQHPISLQ AEVGDGGESS FGDFLEDTAV ESPAEATGYS
490 500 510 520 530 540
MLKDKMKEVL KTLTDRERFV LIHRFGLLDG RPKTLEEVGS AFNVTRERIR QIEAKALRKM
550 560 570
RHPIRSKQLR AFLDLLEEEK IGSGKIKSYK N