P18257

PR
Gene name
Protein name
Neuronal acetylcholine receptor subunit non-alpha-3
Names
GFN-alpha-3
Species
Carassius auratus (Goldfish)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-57 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P18257

Entry ID Method Resolution Chain Position Source
AF-P18257-F1 Predicted AlphaFoldDB

No variants for P18257

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P18257

No associated diseases with P18257

3 regional properties for P18257

Type Name Position InterPro Accession
domain Neurotransmitter-gated ion-channel transmembrane domain 243 - 456 IPR006029
domain Neurotransmitter-gated ion-channel ligand-binding domain 33 - 235 IPR006202
conserved_site Neurotransmitter-gated ion-channel, conserved site 156 - 170 IPR018000

Functions

Description
EC Number
Subcellular Localization
  • Postsynaptic cell membrane; Multi-pass membrane protein
  • Cell membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
postsynaptic membrane A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.

2 GO annotations of molecular function

Name Definition
acetylcholine-gated cation-selective channel activity Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
transmembrane signaling receptor activity Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLQISGLLL VTAVAYATIE APEEFVSLAE MEDTLLRNLF RGYQKWVRPI LHANDTITVR
70 80 90 100 110 120
FGLKISQLVD VDEKNHLMTT NVWLWQEWTD YKLRWNPEDY GGITSIRVPS ETIWLPDIVL
130 140 150 160 170 180
YENADGRFEG SLMTKAIVRF NGTIMWTPPA SYKSSCTMDV TFFPFDRQNC SMKFGSWTYD
190 200 210 220 230 240
GTMVDLTLLD AYVDRKDFFD NGEWEILNAT GQRGSRRDGI YSYPYVTYSF ILKRLPLFYT
250 260 270 280 290 300
LFLIIPCLGL SFLTVLVFYL PSDEGEKLLL STSVLVSLTV FLLVIEEIIP SSSKVIPLIG
310 320 330 340 350 360
EYLLFIMIFV TFSIIVTLFV INVHHRSSAT YHPMAPWVKS LFLQRLPRLL CMRGHTDRYQ
370 380 390 400 410 420
YPDIELRSPE LKRGMKKGQQ KSAGGGRGGL KEDENQAWIA LLEKATHSVH YISRHIKKEH
430 440 450 460
FIREVVQDWK FVAQVLDRIF LWVFLTASVL GTILIFTPAL HMYLST