P18256

PR
Gene name
thrZ (thrS2, BSU37560)
Protein name
Threonine--tRNA ligase 2
Names
Threonyl-tRNA synthetase 2, ThrRS 2
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU37560
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-68 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P18256

Entry ID Method Resolution Chain Position Source
AF-P18256-F1 Predicted AlphaFoldDB

No variants for P18256

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P18256

No associated diseases with P18256

7 regional properties for P18256

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 325 - 530 IPR002314
domain TGS 1 - 64 IPR004095
domain Anticodon-binding 542 - 631 IPR004154
domain Aminoacyl-tRNA synthetase, class II 275 - 535 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 172 - 221 IPR012947
domain Threonine-tRNA ligase catalytic core domain 245 - 540 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 540 - 634 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKHVHIQLP DGQIQEYPKG ITIKEAAGSI SSSLQKKAAA GQVNGKLVDL SFKLEEDAEL
70 80 90 100 110 120
SIVTLDSQEG LQVLRHTTAH VLAQAVKRLY GEVSLGVGPV ILDGFYYDMK LGKSLASGDL
130 140 150 160 170 180
EAIEKEMKNI INENLEIKRI EVSYEEAEEL FAQKDERLKL EILKDIPRGE DITLYQQGEF
190 200 210 220 230 240
VDLCRGPHLP STGMIKAFKL TRVSGAYWRG DSKNEVLQRV YGVAFQKKKD LDAHLHMLEE
250 260 270 280 290 300
AAKRDHRKLG KQLGLFMFSE EAPGMPFYLP KGQIVRNELE RFSRELQTNA GYDEVRTPFM
310 320 330 340 350 360
MNQRLWEQSG HWDHYRDNMY FSEVDDTRFA MKPMNCPGHM LIFKNSLYSY RDLPIRMAEF
370 380 390 400 410 420
GQVHRHEYSG ALNGMLRVRT FCQDDAHIFV REDQIESEIK EAIRLIDEVY RTFGFEYSVE
430 440 450 460 470 480
LSTRPEDSLG DDSLWEASER ALARVLEELG LSYEINEGDG AFYGPKIDFH IKDALKRSHQ
490 500 510 520 530 540
CATIQLDFQM PEKFDLTYIN ELNEKVRPVV IHRAVFGSID RFFGILIEHY GGAFPVWLAP
550 560 570 580 590 600
IQVQIIPVSH VHLDYCRKVQ AELKQAGIRA GIDERNEKLG YKIRESQVQK IPYVLVLGDH
610 620 630
EEQENAVNVR RFGHQQNEHV PFQTFKDKLV KQVENRGM