P18240

PR
Gene name
GGI.R1
Protein name
Glucose-6-phosphate isomerase
Names
GPI, Phosphoglucose isomerase, PGI, Phosphohexose isomerase, PHI
Species
Plasmodium falciparum
KEGG Pathway
EC number
5.3.1.9: Interconverting aldoses and ketoses
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-109 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P18240

Entry ID Method Resolution Chain Position Source
AF-P18240-F1 Predicted AlphaFoldDB

No variants for P18240

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P18240

No associated diseases with P18240

4 regional properties for P18240

Type Name Position InterPro Accession
conserved_site Phosphoglucose isomerase, conserved site 289 - 302 IPR018189-1
conserved_site Phosphoglucose isomerase, conserved site 523 - 540 IPR018189-2
domain Phosphoglucose isomerase, SIS domain 1 124 - 309 IPR035476
domain Phosphoglucose isomerase, SIS domain 2 356 - 546 IPR035482

Functions

Description
EC Number 5.3.1.9 Interconverting aldoses and ketoses
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
carbohydrate derivative binding Binding to a carbohydrate derivative.
glucose-6-phosphate isomerase activity Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate.

2 GO annotations of biological process

Name Definition
gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNMEITNLKS YKELVTLSAE EKTKDLKDYL NDKNRSESLI KKFKNFYMDL SRQRYSEKTL
70 80 90 100 110 120
NKLVEYAEEV ELKKKVEKTF MGEKVNMTEN RSVLHTALRI PIEKINTHKI IIDNKNVLED
130 140 150 160 170 180
VHGVLKKIEK YSDDIRNGVI KTCKNTKFKN VICIGIGGSY LGTEFVYEAM KYYYYNMELN
190 200 210 220 230 240
KNEKDQVNNF NNNYDQDNVF NVRFLANVDP NDVNRAIQNL DQYDTLVIII SKTFTTAETM
250 260 270 280 290 300
LNARSIKKWL SLKIKDDENL SKHMVAVSTN LKLTDEFGIS RDNVFEFWDW VGGRFSVTSS
310 320 330 340 350 360
VGILPLSIAF GYKNMRNFLN GCHDMDEHFL HADLKENIPV LLALTSFYNS HFFDYKNVAI
370 380 390 400 410 420
LPYFQNLLKF SAHIQQLSME SNGKSVDRNN QPIHYNTCQV YFGEPGTNGQ HSFYQLIHQG
430 440 450 460 470 480
QVIPVELIGF KHSHFPIKFD KEVVSNHDEL MTNFFAQADA LAIGKTYEQV KEENEKNKMS
490 500 510 520 530 540
PELLTHKVFN GNRPSTLLLF DELNFYTCGL LLSLYESRIV AEGFLLNINS FDQWGVELGK
550 560 570 580 590
VLAKEVRNYF NDTRNQKKSD NTYNFNESTK NFIKLLLVQI KKKKKINTNL K