P18183

PR
Gene name
hrdB (sigA, SCO5820, SC5B8.10)
Protein name
RNA polymerase principal sigma factor HrdB
Names
BCM1 surface antigen, BLAST-1, HM48-1, MRC OX-45 surface antigen, SLAM family member 2, SLAMF2, Signaling lymphocytic activation molecule 2, sgp-60, RNA polymerase sigma factor SigA
Species
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
KEGG Pathway
sco:SCO5820
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

40-231 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for P18183

Entry ID Method Resolution Chain Position Source
7VPZ EM 414 A F 1-511 PDB
7X74 EM 370 A F 1-511 PDB
7X75 EM 345 A F 1-511 PDB
7X76 EM 367 A F 1-511 PDB
8HVR EM 335 A F 1-511 PDB
8JKE EM 367 A F 1-511 PDB
AF-P18183-F1 Predicted AlphaFoldDB

No variants for P18183

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P18183

No associated diseases with P18183

10 regional properties for P18183

Type Name Position InterPro Accession
domain RNA polymerase sigma-70 302 - 315 IPR000943-1
domain RNA polymerase sigma-70 326 - 334 IPR000943-2
domain RNA polymerase sigma-70 450 - 462 IPR000943-3
domain RNA polymerase sigma-70 471 - 497 IPR000943-4
domain RNA polymerase sigma-70 region 3 357 - 433 IPR007624
domain RNA polymerase sigma-70 region 2 278 - 347 IPR007627
domain RNA polymerase sigma-70 region 4 446 - 499 IPR007630
domain RNA polymerase sigma-70 region 1.2 213 - 246 IPR009042
domain RNA polymerase sigma factor RpoD, C-terminal 274 - 510 IPR012760
domain RNA polymerase sigma-70 like domain 274 - 499 IPR014284

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
bacterial-type RNA polymerase holo enzyme binding Binding to a component of the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
sigma factor activity Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins.

1 GO annotations of biological process

Name Definition
DNA-templated transcription initiation The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSASTSRTLP PEIAESVSVM ALIERGKAEG QIAGDDVRRA FEADQIPATQ WKNVLRSLNQ
70 80 90 100 110 120
ILEEEGVTLM VSAAEPKRTR KSVAAKSPAK RTATKAVAAK PVTSRKATAP AAPAAPATEP
130 140 150 160 170 180
AAVEEEAPAK KAAAKKTTAK KATAKKTTAK KAAAKKTTAK KEDGELLEDE ATEEPKAATE
190 200 210 220 230 240
EPEGTENAGF VLSDEDEDDA PAQQVAAAGA TADPVKDYLK QIGKVPLLNA EQEVELAKRI
250 260 270 280 290 300
EAGLFAEDKL ANSDKLAPKL KRELEIIAED GRRAKNHLLE ANLRLVVSLA KRYTGRGMLF
310 320 330 340 350 360
LDLIQEGNLG LIRAVEKFDY TKGYKFSTYA TWWIRQAITR AMADQARTIR IPVHMVEVIN
370 380 390 400 410 420
KLARVQRQML QDLGREPTPE ELAKELDMTP EKVIEVQKYG REPISLHTPL GEDGDSEFGD
430 440 450 460 470 480
LIEDSEAVVP ADAVSFTLLQ EQLHSVLDTL SEREAGVVSM RFGLTDGQPK TLDEIGKVYG
490 500 510
VTRERIRQIE SKTMSKLRHP SRSQVLRDYL D