P18140

PR
Gene name
N
Protein name
Nucleoprotein
Names
Nucleocapsid protein, Protein N
Species
Tacaribe virus (strain Franze-Fernandez) (TCRV)
KEGG Pathway
vg:956597
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-159 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P18140

Entry ID Method Resolution Chain Position Source
4GVE X-ray 173 A A 364-570 PDB

No variants for P18140

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P18140

No associated diseases with P18140

2 regional properties for P18140

Type Name Position InterPro Accession
domain Nucleocapsid, N-terminal, Arenaviridae 4 - 334 IPR035083
domain Nucleocapsid, C-terminal, Arenaviridae 360 - 545 IPR035084

Functions

Description
EC Number
Subcellular Localization
  • Virion
  • Host cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
helical viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form a protein helix with the genetic material contained within. Tobacco mosaic virus has such a capsid structure.
host cell cytoplasm The cytoplasm of a host cell.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.
viral nucleocapsid The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle.

3 GO annotations of molecular function

Name Definition
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
metal ion binding Binding to a metal ion.
RNA binding Binding to an RNA molecule or a portion thereof.

3 GO annotations of biological process

Name Definition
negative stranded viral RNA replication A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA).
RNA-templated viral transcription A transcription process that uses viral RNA as a template.
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAQSKEVPSF RWTQSLRKGL SQFTQTVKSD ILKDAKLIAD SIDFNQVAQV QRVLRKTKRT
70 80 90 100 110 120
DDDLNKLRDL NIEVDRLMSM KSVQKNTIFK VGDLARDELM ELASDLEKLK DKIKRTESNG
130 140 150 160 170 180
TNAYMGNLPQ SQLNRRSEIL RTLGFAQQGG RPNGIVRVWD VKDSSKLNNQ FGSMPALTIA
190 200 210 220 230 240
CMTVQGGETM NNVVQALTSL GLLYTVKYPN LSDLDKLIPN HECLQIITKE ESSINISGYN
250 260 270 280 290 300
LSLLAAVKAG ASILDGGNML ETIRVSPDNF SSLIKNTLQV KRREGMFIDD RPGSRNPYEN
310 320 330 340 350 360
LLYKLCLSGD GWPYIGSRSQ IMGRSWDNTS VDLTKKPDAV PEPGAAPRPA ERKGQNLRLA
370 380 390 400 410 420
SLTEGQELIV RAAISELDPS NTIWLDIEDL QLDPVELALY QPAKKQYIHC FRKPHDEKGF
430 440 450 460 470 480
KNGSRHSHGI LMKDIEDAVP GVLSYVIGLL PPNMVITTQG SDDIRKLLDI HGRKDLKLID
490 500 510 520 530 540
VKFTSDQARL FEHQVWDKFG HLCKQHNGVI ISKKNKSKDS PPSPSPDEPH CALLDCIMFH
550 560
SAVSGELPKE EPIPLLPKEF LFFPKTAFAL