P18119

PR
Gene name
thrb-b (nr1a2-b, thrb2)
Protein name
Thyroid hormone receptor beta-B
Names
TRbetaB, Nuclear receptor subfamily 1 group A member 2-B
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:397734
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

107-236 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P18119

Entry ID Method Resolution Chain Position Source
AF-P18119-F1 Predicted AlphaFoldDB

No variants for P18119

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P18119

No associated diseases with P18119

2 regional properties for P18119

Type Name Position InterPro Accession
domain Nuclear hormone receptor, ligand-binding domain 170 - 414 IPR000536
domain Zinc finger, nuclear hormone receptor-type 57 - 134 IPR001628

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
nuclear receptor activity A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
zinc ion binding Binding to a zinc ion (Zn).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPSSMSVRLF TASAAQRKKI QEGDCCVVLA GKTQGRFILI GAVARVSGYI PSYLDKDELC
70 80 90 100 110 120
VVCGDKATGY HYRCITCEGC KGFFRRTIQK NLHPSYSCKY EGKCVIDKVT RNQCQECRFK
130 140 150 160 170 180
KCKTVGMATD LVLDDSKRLA KRKLIEENRE KRRKDEIQKS IVQRPEPTQE EWELIQVVTE
190 200 210 220 230 240
AHVATNAQGS HWKQKRKFLP EDIGQAPIVN APEGGKVDLE AFSQFTKIIT PAITRVVDFA
250 260 270 280 290 300
KKLPMFCELP CEDQIILLKG CCMEIMSLRA AVRYDPESET LTLNGEMAVT RGQLKNGGLG
310 320 330 340 350 360
VVSDAIFDLG VSLSSFSLDD TEVALLQAVL LMSSDRPGLS SVERIEKCQE GFLLAFEHYI
370 380 390 400 410
NYRKHNIAHF WPKLLMKVTD LRMIGACHAS RFLHMKVECP TELFPPLFLE VFED