P18117
Gene name |
thrb-a (nr1a2-a, thrb1) |
Protein name |
Thyroid hormone receptor beta-A |
Names |
TRbetaA, xTR, Nuclear receptor subfamily 1 group A member 2-A |
Species |
Xenopus laevis (African clawed frog) |
KEGG Pathway |
xla:779054 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P18117
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P18117-F1 | Predicted | AlphaFoldDB |
No variants for P18117
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P18117 | |||||
No associated diseases with P18117
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| nuclear receptor activity | A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
| thyroid hormone binding | Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland. |
| zinc ion binding | Binding to a zinc ion (Zn). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPSSMSGYIP | SYLDKDELCV | VCGDKATGYH | YRCITCEGCK | GFFRRTIQKN | LHPSYSCKYE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GKCVIDKVTR | NQCQECRFKK | CIAVGMATDL | VLDDNKRLAK | RKLIEENREK | RRKDEIQKSL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VQKPEPTQEE | WELIQVVTEA | HVATNAQGSH | WKQKRKFLPE | DIGQAPIVNA | PEGGKVDLEA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FSQFTKIITP | AITRVVDFAK | KLPMFCELPC | EDQIILLKGC | CMEIMSLRAA | VRYDPESETL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TLNGEMAVTR | GQLKNGGLGV | VSDAIFDLGV | SLSSFSLDDT | EVALLQAVLL | MSSDRPGLAS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VERIEKCQEG | FLLAFEHYIN | YRKHNIAHFW | PKLLMKVTDL | RMIGACHASR | FLHMKVECPT |
| 370 | |||||
| ELFPPLFLEV | FED |