AiPD: Autoinhibited Protein Database

Gene name	cysI (b2763, JW2733)
Protein name	Sulfite reductase [NADPH] hemoprotein beta-component
Names	SiR-HP, SiRHP
Species	Escherichia coli (strain K12)
KEGG Pathway	eco:b2763
EC number	1.8.1.2: With NAD(+) or NADP(+) as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-53 (Predicted disordered autoinhibitory region) PR

1-53 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
1AOP	X-ray	160 A	A	74-570	PDB
2AOP	X-ray	175 A	A	74-570	PDB
2GEP	X-ray	190 A	A	74-570	PDB
3AOP	X-ray	210 A	A	74-570	PDB
3GEO	X-ray	210 A	A	74-570	PDB
4AOP	X-ray	180 A	A	74-570	PDB
4G38	X-ray	156 A	A	1-570	PDB
4G39	X-ray	240 A	A	1-570	PDB
4GEP	X-ray	200 A	A	74-570	PDB
4HTR	X-ray	160 A	A	64-570	PDB
5AOP	X-ray	220 A	A	74-570	PDB
5GEP	X-ray	210 A	A	74-570	PDB
6C3M	X-ray	150 A	A	1-570	PDB
6C3X	X-ray	154 A	A	1-570	PDB
6C3Y	X-ray	154 A	A	1-570	PDB
6C3Z	X-ray	168 A	A	1-570	PDB
6GEP	X-ray	180 A	A	74-570	PDB
7GEP	X-ray	240 A	A	74-570	PDB
8GEP	X-ray	220 A	A	74-570	PDB
AF-P17846-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for P17846

Type	Name	Position	InterPro Accession
binding_site	Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site	35 - 53	IPR001216
domain	Tryptophan synthase beta chain-like, PALP domain	9 - 294	IPR001926

		Description
EC Number	1.8.1.2	With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
sulfite reductase complex (NADPH)	A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide.

Name	Definition
4 iron, 4 sulfur cluster binding	Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
heme binding	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
metal ion binding	Binding to a metal ion.
NADP binding	Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
sulfite reductase (ferredoxin) activity	Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = sulfite + 3 reduced ferredoxin.
sulfite reductase (NADPH) activity	Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+.
sulfite reductase activity	Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor.

Name	Definition
cysteine biosynthetic process	The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid.
hydrogen sulfide biosynthetic process	The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S.
sulfate assimilation	The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins