P17779

PR
Gene name
Protein name
RNA replication protein
Names
165 kDa protein, ORF1 protein
Species
Potato virus X (strain X3) (PVX)
KEGG Pathway
vg:7065759
EC number
2.7.7.48: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

496-585 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for P17779

Entry ID Method Resolution Chain Position Source

No variants for P17779

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P17779

No associated diseases with P17779

4 regional properties for P17779

Type Name Position InterPro Accession
domain RNA-dependent RNA polymerase, alsuviricetes 1127 - 1397 IPR001788
domain Alphavirus-like methyltransferase (MT) domain 39 - 339 IPR002588
domain RNA-directed RNA polymerase, catalytic domain 1236 - 1343 IPR007094
domain (+) RNA virus helicase core domain 695 - 997 IPR027351

Functions

Description
EC Number 2.7.7.48 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
mRNA methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

3 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
positive stranded viral RNA replication A viral genome replication process where the template genome is positive stranded, single stranded RNA ((+)ssRNA). Replication of the positive strand leads to dsRNA formation, which in turn is transcribed into positive single stranded RNA.
RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAKVREVYQS FTDSTTKTLI QDEAYRNIRP IMEKHKLANP YAQTVEAAND LEGFGIATNP
70 80 90 100 110 120
YSIELHTHAA AKTIENKLLE VLGSILPQEP VTFMFLKPRK LNYMRRNPRI KDIFHNVAIE
130 140 150 160 170 180
PRDVARYPKE TIIDKLTEIT TETAYISDTL HFLDPSYIVE TFQNCPKLQT LYATLVLPVE
190 200 210 220 230 240
AAFKMESTHP NIYSLKYFGD GFQYIPGNHG GGAYHHEFAH LQWLKVGKIK WRDPKDSFLG
250 260 270 280 290 300
HLNYTTEQVE MHTVTVQLQE SFAANHLYCI RRGDLLTPEV RTFGQPDRYV IPPQIFLPKV
310 320 330 340 350 360
HNCKKPILKK TMMQLFLYVR TVKVAKNCDI FAKVRQLIKS SDLDKYSAVE LVYLVSYMEF
370 380 390 400 410 420
LADLQATTCF SDTLSGGLLT KTLAPVRAWI QEKKMQLFGL EDYAKLVKAV DFHPVDFSFK
430 440 450 460 470 480
VETWDFRFHP LQAWKAFRPR EVSDVEEMES LFSDGDLLDC FTRMPAYAVN AEEDLATIRK
490 500 510 520 530 540
TPEMDVGQEV KEPAGDRNQY SNPAETFLNK LHRKHSREVK HQAVKKAKRL AEIQESMRAE
550 560 570 580 590 600
GEAEPNETSG GMGAIPSNAE LPGTSDARQE LTLPTTKPVP ARWEDASFTD SSVEEEQVRL
610 620 630 640 650 660
LGEEAVKTAT QQVIEGLPWK HWIPQLNAVG FKALLIQRDR SGTMIMPITE MVSGLEKEDF
670 680 690 700 710 720
PEGTPKELAR ELLVMNRSPA TIPLDLLRAR DYGSDVKNKR IGAITKTQAT SWGEYLTGKI
730 740 750 760 770 780
ESLTERKVAT CVIHGAGGSG KSHAIQKALR EIGKGSDITV VLPTNELRLD WSKKVPNTEP
790 800 810 820 830 840
YMFKTYEKAL IGGTGSIVIF DDYSKLPPGY IEALVCFYSK IKLIILTGDS RQSVYHETAE
850 860 870 880 890 900
DASIRHLGPA TEYFSKYCRY YLNATHRNKK DLANMLGVYS ERTGVTEISM SAEFLEGIPT
910 920 930 940 950 960
LVPSDEKRKL YMGTGRNDTF TYAGCQGLTK PKVQIVLDHN TQVCSANVMY TALSRATDRI
970 980 990 1000 1010 1020
HFVNTSANSS AFWEKLDSTP YLKTFLSVVR EQALREYEPA EAEPIQEPEP QTHMCVENEE
1030 1040 1050 1060 1070 1080
SVLEEYKEEL LEKFDREIHS ESHGHSNCVQ TEDTTIQLFS HQQAKDETLL WATIDARLKT
1090 1100 1110 1120 1130 1140
SNQEANFREF LSKKDIGDVL FLNYQKAMGL PKERIPFSQE VWEACAHEVQ SKYLSKSKCN
1150 1160 1170 1180 1190 1200
LINGTVRQSP DFDENKIMVF LKSQWVTKVE KLGLPKIKPG QTIAAFYQQT VMLFGTMARY
1210 1220 1230 1240 1250 1260
MRWFRQAFQP KEVFINCETT PEDMSVWALN NWNFSRPSLA NDYTAFDQSQ DGAMLQFEVL
1270 1280 1290 1300 1310 1320
KAKHHCIPEE IIQAYIDIKT NAQIFLGTLS IMRLTGEGPT FDANTECNIA YTHTKFDIPA
1330 1340 1350 1360 1370 1380
GTAQVYAGDD SALDCVPEVK HSFHRLEDKL LLKSKPVITQ QKKGSWPEFC GWLITPKGVM
1390 1400 1410 1420 1430 1440
KDPIKLHVSL KLAEAKGELK KCQDSYEIDL SYAYDHKDSL HDLFDEKQCQ AHTLTCRTLI
1450
KSGRGTVSLP RLRNFL