P17770
Gene name |
TDC |
Protein name |
Aromatic-L-amino-acid decarboxylase |
Names |
AADC, DOPA decarboxylase, Tryptophan decarboxylase |
Species |
Catharanthus roseus (Madagascar periwinkle) (Vinca rosea) |
KEGG Pathway |
ag:CAA47898 |
EC number |
4.1.1.28: Carboxy-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P17770
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6EEW | X-ray | 205 A | A/B/C/D | 1-500 | PDB |
| AF-P17770-F1 | Predicted | AlphaFoldDB |
No variants for P17770
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P17770 | |||||
No associated diseases with P17770
1 regional properties for P17770
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| binding_site | Pyridoxal-phosphate binding site | 312 - 333 | IPR021115 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.1.28 | Carboxy-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5-hydroxy-L-tryptophan decarboxylase activity | Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin. |
| L-tryptophan decarboxylase activity | Catalysis of the reaction: L-tryptophan + H+ = CO2 + tryptamine. |
| pyridoxal phosphate binding | Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular amino acid metabolic process | The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. |
| organonitrogen compound biosynthetic process | The chemical reactions and pathways resulting in the formation of organonitrogen compound. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGSIDSTNVA | MSNSPVGEFK | PLEAEEFRKQ | AHRMVDFIAD | YYKNVETYPV | LSEVEPGYLR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KRIPETAPYL | PEPLDDIMKD | IQKDIIPGMT | NWMSPNFYAF | FPATVSSAAF | LGEMLSTALN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SVGFTWVSSP | AATELEMIVM | DWLAQILKLP | KSFMFSGTGG | GVIQNTTSES | ILCTIIAARE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RALEKLGPDS | IGKLVCYGSD | QTHTMFPKTC | KLAGIYPNNI | RLIPTTVETD | FGISPQVLRK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MVEDDVAAGY | VPLFLCATLG | TTSTTATDPV | DSLSEIANEF | GIWIHVDAAY | AGSACICPEF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RHYLDGIERV | DSLSLSPHKW | LLAYLDCTCL | WVKQPHLLLR | ALTTNPEYLK | NKQSDLDKVV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DFKNWQIATG | RKFRSLKLWL | ILRSYGVVNL | QSHIRSDVAM | GKMFEEWVRS | DSRFEIVVPR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NFSLVCFRLK | PDVSSLHVEE | VNKKLLDMLN | STGRVYMTHT | IVGGIYMLRL | AVGSSLTEEH |
| 490 | |||||
| HVRRVWDLIQ | KLTDDLLKEA |