P17713
Gene name |
STK |
Protein name |
Tyrosine-protein kinase STK |
Names |
P57-STK |
Species |
Hydra vulgaris (Hydra) (Hydra attenuata) |
KEGG Pathway |
hmg:100198593 |
EC number |
2.7.10.2: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
377-401 (Activation loop from InterPro)
Target domain |
240-495 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for P17713
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P17713-F1 | Predicted | AlphaFoldDB |
No variants for P17713
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P17713 | |||||
No associated diseases with P17713
7 regional properties for P17713
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 240 - 495 | IPR000719 |
| domain | SH2 domain | 124 - 218 | IPR000980 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 240 - 487 | IPR001245 |
| domain | SH3 domain | 59 - 120 | IPR001452 |
| active_site | Tyrosine-protein kinase, active site | 356 - 368 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 246 - 268 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 240 - 490 | IPR020635 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.2 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| non-membrane spanning protein tyrosine kinase activity | Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGPCCSKQTK | ALNNQPDKSK | SKDVVLKENT | SPFSQNTNNI | MHVSHNQPPN | INPPMLGGPG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VTIFVALYDY | EARISEDLSF | KKGERLQIIN | TADGDWWYAR | SLITNSEGYI | PSTYVAPEKS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YEAEEWYFGD | VKRAEAEKRL | MVRGLPSGTF | LIRKAETAVG | NFSLSVRDGD | SVKHYRVRKL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DTGGYFITTR | APFNSLYELV | QHYTKDADGL | VCALTLPCPK | DKPVTGGIAK | DAWEIPRESL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RLNRKLGAGQ | FGEVWAGVWN | NTTQVAVKTL | KPGTMSPASF | LDEAGVMKKL | RHKHLVQLYA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ICSDREPIYI | VTEYMSGGSL | LDYLSKGEGV | NLQLPTLIDM | AAQVASGMAF | LEAQGYIHRD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LAARNILVGE | NYICKVADFG | LARLIEDDEY | TAHEGAKFPI | KWTAPEAALY | NRFTIKSDVW |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SFGILMAEIV | TKGRIPYPGM | TNAQTIAEVE | KGYRMPIMPG | CPEPLYNIML | QTWNKDPENR |
| 490 | 500 | ||||
| PTFDYLQGVL | EDYFVSTEQG | YRDLGEANS |