P17442
Gene name |
PHO81 (YGR233C, G8567) |
Protein name |
Phosphate system positive regulatory protein PHO81 |
Names |
CDK inhibitor PHO81 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGR233C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P17442
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P17442-F1 | Predicted | AlphaFoldDB |
26 variants for P17442
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-958081 | 45 | L>I | No | SGRP | |
| s07-957513 | 234 | N>S | No | SGRP | |
| s07-957468 | 249 | I>T | No | SGRP | |
| s07-957460 | 252 | N>D | No | SGRP | |
| s07-957429 | 262 | S>L | No | SGRP | |
| s07-956699 | 505 | K>N | No | SGRP | |
| s07-956649 | 522 | A>V | No | SGRP | |
| s07-956254 | 654 | A>S | No | SGRP | |
| s07-956185 | 677 | D>N | No | SGRP | |
| s07-955945 | 757 | I>V | No | SGRP | |
| s07-955935 | 760 | V>G | No | SGRP | |
| s07-955822 | 798 | D>N | No | SGRP | |
| s07-955699 | 839 | M>V | No | SGRP | |
| s07-955694 | 840 | N>K | No | SGRP | |
| s07-955595 | 873 | N>K | No | SGRP | |
| s07-955443 | 924 | Y>F | No | SGRP | |
| s07-955311 | 968 | S>W | No | SGRP | |
| s07-955302 | 971 | V>A | No | SGRP | |
| s07-955289 | 975 | S>R | No | SGRP | |
| s07-955263 | 984 | A>V | No | SGRP | |
| s07-955249 | 989 | R>G | No | SGRP | |
| s07-955107 | 1036 | S>N | No | SGRP | |
| s07-955011 | 1068 | N>S | No | SGRP | |
| s07-955005 | 1070 | L>H | No | SGRP | |
| s07-954729 | 1162 | S>N | No | SGRP | |
| s07-954684 | 1177 | D>G | No | SGRP |
No associated diseases with P17442
5 regional properties for P17442
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Ankyrin repeat | 410 - 488 | IPR002110-1 |
| repeat | Ankyrin repeat | 506 - 535 | IPR002110-2 |
| repeat | Ankyrin repeat | 556 - 653 | IPR002110-3 |
| domain | SPX domain | 1 - 169 | IPR004331 |
| domain | Glycerophosphodiester phosphodiesterase domain | 871 - 1178 | IPR030395 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cyclin-dependent protein serine/threonine kinase inhibitor activity | Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. |
| phosphoric diester hydrolase activity | Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| lipid metabolic process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. |
| phosphate-containing compound metabolic process | The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKFGKYLEAR | QLELAEYNSH | FIDYKALKKL | IKQLAIPTLK | ASSDLDLHLT | LDDIDEKIIH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QRLQENKAAF | FFKLERELEK | VNGYYLARES | DLRIKFNILH | SKYKDYKING | KLNSNQATSF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KNLYAAFKKF | QKDLRNLEQY | VELNKTGFSK | ALKKWDKRSQ | SHDKDFYLAT | VVSIQPIFTR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DGPLKLNDET | LHILLELNDI | DNNNRRADIQ | SSTFTNDDDD | DNNTSNNNKH | NNNNNNNNNN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NNNNNNNNIL | HNNYELTTSK | ISENQLEHLF | QASSSSLDME | MEIENWYKEI | LNIATVKDVQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RKHALLRNFR | ETKIFTYLLQ | NSSESFHKNV | FSLLKECLTT | LFLLLVASPL | DDNSLHIFYK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SNQDHIDLSY | CDEDDQVFSR | KNVFHEAASC | PEKSRLFILD | EALTTSKLSK | ETVQKLLNAQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DIHSRVPLHY | AAELGKLEFV | HSLLITNLLE | DVDPIDSDSK | TPLVLAITNN | HIDVVRDLLT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IGGANASPIE | KPILDYSKNV | ISSTKVQFDP | LNVACKFNNH | DAAKLLLEIR | SKQNADNAKN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KSSQHLCQPL | FKKNSTGLCT | LHIVAKIGGD | PQLIQLLIRY | GADPNEIDGF | NKWTPIFYAV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RSGHSEVITE | LLKHNARLDI | EDDNGHSPLF | YALWESHVDV | LNALLQRPLN | LPSAPLNEIN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SQSSTQRLNT | IDLTPNDDKF | DLDIQDSIPD | FALPPPIIPL | RKYGHNFLEK | KIFIKLKLRP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GLESIKLTQD | NGIIMSSSPG | RITLSSNLPE | IIPRNVILPV | RSGEINNFCK | DISETNDEED |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DDEISEDHDD | GEIIFQVDSI | DDFSMDFEIF | PSFGTRIIAK | TTAMPFLFKK | VAINSIATMN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LPLFDTRLNN | IGSLTLDYQI | IFPYPGNPLK | IINYEPYWKS | TGSDLMTSSK | DGNFVTSSSL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| NGSFISVLVC | ALNDETIVAA | PKPYVEFKGT | KILLNDLTKE | QLEKVVDYDF | GKIDGSFDEV |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| TLKQYLSSRV | VPLRSLLEVI | PGSAQLVIRV | YFPTDKEIDT | IPIKISPFIN | INQFIDKLLL |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| IIFEHERFLR | HSGSGSMRQI | VFSSCNWEAC | SILNWKQPNF | PVLLQMKNLL | RDSTTGKFVG |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| DTPNCLKELA | VNPQKMSYLN | TELINIHTMV | QFAMNNNLLG | VTLPYEVLKI | CPSLARIIKQ |
| 1150 | 1160 | 1170 | |||
| NGLLLIASVG | ENDQIPADGG | YSGIYYACEL | LFENNIDM |