AiPD: Autoinhibited Protein Database

Gene name	WARS1 (WARS)
Protein name	Tryptophan--tRNA ligase, cytoplasmic
Names	Tryptophanyl-tRNA synthetase, TrpRS
Species	Bos taurus (Bovine)
KEGG Pathway	bta:281576
EC number	6.1.1.2: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-118 (Predicted disordered autoinhibitory region) PR

1-118 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P17248-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs463033649	2	A>S	No	EVA
rs477663997	4	M>I	No	EVA
rs439646614	4	M>K	No	EVA
rs460707386	10	G>C	No	EVA
rs440740515	10	G>D	No	EVA
rs454559497	11	C>G	No	EVA
rs444024548	11	C>S	No	EVA
rs475373237	13	S>P	No	EVA
rs452131042	22	A>S	No	EVA
rs466771840	24	Q>E	No	EVA
rs436284132	24	Q>H	No	EVA
rs453071301	24	Q>P	No	EVA
rs450670550	25	G>E	No	EVA
rs467478777	25	G>R	No	EVA
rs437973212	30	D>A	No	EVA
rs469362386	30	D>E	No	EVA
rs446102336	31	L>P	No	EVA
rs434462272	32	K>E	No	EVA
rs460741328	33	A>P	No	EVA
rs481745738	35	N>T	No	EVA
rs444713621	36	A>G	No	EVA
rs461664497	36	A>P	No	EVA
rs458506031	37	A>P	No	EVA
rs455350316	45	V>M	No	EVA
rs461448545	65	V>A	No	EVA
rs451111377	70	G>R	No	EVA
rs451111377	70	G>W	No	EVA
rs463510261	79	G>V	No	EVA
rs443560560	88	D>H	No	EVA
rs457429348	103	I>V	No	EVA
rs471649983	106	D>V	No	EVA
rs447622412	110	V>D	No	EVA
rs517937759	263	V>I	No	EVA
rs434457222	319	D>A	No	EVA
rs465962692	326	R>W	No	EVA
rs449088520	327	D>N	No	EVA
rs435348560	333	G>A	No	EVA
rs524529221	333	G>S	No	EVA
rs470078154	334	Y>S	No	EVA
rs449958807	341	H>N	No	EVA
rs476402589	418	L>V	No	EVA
rs476043884	428	G>R	No	EVA
rs452768093	439	L>R	No	EVA
rs432637046	445	P>H	No	EVA
rs452804502	450	H>D	No	EVA
rs435920749	454	R>P	No	EVA
rs467304589	455	K>Q	No	EVA
rs450456262	457	V>D	No	EVA
rs437020680	461	I>F	No	EVA
rs445126470	466	M>K	No	EVA

Type	Name	Position	InterPro Accession
domain	WHEP-TRS domain	13 - 73	IPR000738
conserved_site	Aminoacyl-tRNA synthetase, class I, conserved site	169 - 179	IPR001412

		Description
EC Number	6.1.1.2	Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase inhibitor activity	Binds to and stops, prevents or reduces the activity of a kinase.
protein domain specific binding	Binding to a specific domain of a protein.
protein homodimerization activity	Binding to an identical protein to form a homodimer.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
tryptophan-tRNA ligase activity	Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp).

Name	Definition
negative regulation of protein kinase activity	Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of protein-containing complex assembly	Any process that activates or increases the frequency, rate or extent of protein complex assembly.
regulation of angiogenesis	Any process that modulates the frequency, rate or extent of angiogenesis.
regulation of protein ADP-ribosylation	Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids.
tryptophanyl-tRNA aminoacylation	The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P23381	WARS1	Tryptophan--tRNA ligase, cytoplasmic	Homo sapiens (Human)	PR