P17247

PR
Gene name
tgfb2
Protein name
Transforming growth factor beta-2 proprotein
Names
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:373801
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

17-123 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P17247

Entry ID Method Resolution Chain Position Source
AF-P17247-F1 Predicted AlphaFoldDB

No variants for P17247

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P17247

No associated diseases with P17247

3 regional properties for P17247

Type Name Position InterPro Accession
domain TGF-beta, propeptide 22 - 227 IPR001111
domain Transforming growth factor-beta, C-terminal 298 - 413 IPR001839
conserved_site Transforming growth factor beta, conserved site 334 - 349 IPR017948

Functions

Description
EC Number
Subcellular Localization
  • [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

2 GO annotations of molecular function

Name Definition
growth factor activity The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
transforming growth factor beta receptor binding Binding to a transforming growth factor beta receptor.

3 GO annotations of biological process

Name Definition
embryo development The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
positive regulation of cell division Any process that activates or increases the frequency, rate or extent of cell division.
tissue development The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MHYYVLFTFL TLDLAPVALS LSTCSALDMD QFMRKRIEAI RGQILSKLKL NSPPEDYPEP
70 80 90 100 110 120
GEVSQDVISI YNSTRDLLQE KANERATSCE RERSEDEYYA KEVYKIDMLP YYTSENVIPP
130 140 150 160 170 180
SYTTPYFRIV RFDVSSMEKN ASNLVKAEFR VFRLMNTKAR VSEQRIELYQ ILKSKDLASP
190 200 210 220 230 240
TQRYIDSKVV KTRAEGEWLS FDVTEAVNEW LHHKDRNLGF KISLHCPCCT FIPSNNYIIP
250 260 270 280 290 300
NKSEELETRF AGIDDAYMYA GGDSKSKTGR KKHTGRTPHL LLMLLPSYRL ESQQSSRRKK
310 320 330 340 350 360
RALDAAYCFR NVQDNCCLRP LYIDFKKDLG WKWIHEPKGY NANFCAGACP YLWSSDTQHS
370 380 390 400 410
RVLSLYNTIN PEASASPCCV SQDLDSLTIL YYIGNKPKIE QLSNMIVKSC KCS