P16667
Gene name |
sau3AIR |
Protein name |
Type II restriction enzyme Sau3AI |
Names |
R.Sau3AI, Endonuclease Sau3AI, Type-2 restriction enzyme Sau3AI |
Species |
Staphylococcus aureus |
KEGG Pathway |
|
EC number |
3.1.21.4: Endodeoxyribonucleases producing 5'-phosphomonoesters |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P16667
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2REU | X-ray | 190 A | A | 233-489 | PDB |
| 4PXG | X-ray | 245 A | A/B | 1-489 | PDB |
| 7XM0 | X-ray | 260 A | A/B/C | 233-489 | PDB |
| AF-P16667-F1 | Predicted | AlphaFoldDB |
No variants for P16667
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P16667 | |||||
No associated diseases with P16667
1 regional properties for P16667
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA mismatch repair MutH/Type II restriction enzyme Sau3AI | 46 - 150 | IPR011337 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.21.4 | Endodeoxyribonucleases producing 5'-phosphomonoesters |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| type II site-specific deoxyribonuclease activity | Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA restriction-modification system | A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESYLTKQAV | HNRAKEAVGK | SVLELNGGES | IKQSKSSVGD | AFENWFGKKK | DSDSKPDMAE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AGVELKATPF | KKLKNGKYSS | KERLVLNIIN | YEKVANENFE | TSSFLSKNNT | IELAFYEYIK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GTPSDNWIIK | EAVLYEMHKN | PIDYEIIKQD | WEIINQYINE | GKAHELSEGL | TSYLAPCTKG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ANASSLRNQP | YSDIKAKQRA | FSLKSGYMTS | ILRKYVLGDE | KIDSIVKDPF | EIKEKSIEDI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VFEKFQPYIN | WSIDKLCEHF | SINKGEKGLN | YRIASAILNL | KGKTTKSKPF | PEVEEFEKSS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IVVKTVHFNK | KNVNKESMSF | GAFKFEELAN | EEWEDSEGYP | SAQWRNFLLE | TRFLFFVVKE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DEDGVDIFKG | IKFFSMPEED | INGPVKRMWD | DTVKKLKEGV | TLEAVPDKST | KDGWRIKNNF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VDKSDDLICH | VRPHTNNRDY | RGGSNADKLP | KKINWINRPD | SDDYSDEWMT | KQSFWINNDY |
| IKKQVEDLL |