AiPD: Autoinhibited Protein Database

P16455

Gene name	MGMT
Protein name	Methylated-DNA--protein-cysteine methyltransferase
Names	6-O-methylguanine-DNA methyltransferase, MGMT, O-6-methylguanine-DNA-alkyltransferase
Species	Homo sapiens (Human)
KEGG Pathway	hsa:4255
EC number	2.1.1.63: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

161-207 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

161-207 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

8 structures for P16455

Entry ID	Method	Resolution	Chain	Position	Source
1EH6	X-ray	200 A	A	1-207	PDB
1EH7	X-ray	200 A	A	1-207	PDB
1EH8	X-ray	250 A	A	1-207	PDB
1QNT	X-ray	190 A	A	1-176	PDB
1T38	X-ray	320 A	A	1-176	PDB
1T39	X-ray	330 A	A/B	1-176	PDB
1YFH	X-ray	301 A	A/B/C	1-179	PDB
AF-P16455-F1	Predicted				AlphaFoldDB

202 variants for P16455

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs757127526 CA5747925	4	D>H		No	ClinGen ExAC TOPMed gnomAD
CA378909876 rs1371989505	4	D>V		No	ClinGen gnomAD
CA5747926 rs536098805	5	C>Y		No	ClinGen 1000Genomes ExAC gnomAD
rs750429640 CA5747927	7	M>I		No	ClinGen ExAC gnomAD
rs141095230 CA5747928	9	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs544050191 CA5747929	9	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA215998231 rs544050191	9	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs544050191 CA378909913	9	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs141095230 CA378909911	9	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1029449695 CA215998232	10	T>I		No	ClinGen Ensembl
rs1564845409 CA378909936	13	D>E		No	ClinGen Ensembl
rs201016048 CA5747931	15	P>S		No	ClinGen ExAC gnomAD
rs953928301 CA215998233	16	L>S		No	ClinGen TOPMed gnomAD
CA378909972 rs1224062330	19	L>V		No	ClinGen gnomAD
CA378909982 rs1247292713	20	E>D		No	ClinGen gnomAD
CA378909976 rs1165271359	20	E>K		No	ClinGen TOPMed
rs1362990752 CA378910003	23	G>D		No	ClinGen TOPMed
rs368258514 CA5747934	24	C>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs368258514 CA215998235	24	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA5747935 rs771392791	25	E>G		No	ClinGen ExAC TOPMed gnomAD
CA378910046 rs1473225094	26	Q>H		No	ClinGen gnomAD
rs1187625712 CA378910058	27	G>V		No	ClinGen gnomAD
CA5747938 rs2020893	30	E>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs2020893 CA5747937 VAR_014750 RCV000733594 RCV000973453	30	E>K		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA378910085 rs2020893	30	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5747939 rs775096561	33	L>F		No	ClinGen ExAC gnomAD
rs918303726 CA215998236	37	G>A		No	ClinGen Ensembl
rs1299423070 CA378910170	38	T>A		No	ClinGen gnomAD
rs763636757 CA5747941	38	T>M		No	ClinGen ExAC TOPMed gnomAD
CA5747944 rs375192201	42	D>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA5747943 rs372458519	42	D>N		No	ClinGen ESP ExAC gnomAD
CA5747968 rs753839323	43	A>V		No	ClinGen ExAC TOPMed gnomAD
CA5747973 rs373527392	44	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5747972 rs373527392	44	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA378911770 rs1310282399	45	E>D		No	ClinGen TOPMed
rs1343221139 CA378911773	46	V>F		No	ClinGen TOPMed gnomAD
rs1343221139 CA378911771	46	V>I		No	ClinGen TOPMed gnomAD
CA378911786 rs1437096089	48	A>D		No	ClinGen gnomAD
rs923830226 CA216020346	49	P>A		No	ClinGen TOPMed
CA378911792 rs1317932653	49	P>R		No	ClinGen TOPMed
rs780706260 CA378911795	50	A>S		No	ClinGen ExAC TOPMed gnomAD
rs780706260 CA5747976	50	A>T		No	ClinGen ExAC TOPMed gnomAD
COSM2151781 CA5747978 rs749868332	51	A>V	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1379733653 CA378911809	52	V>D		No	ClinGen TOPMed
CA5748012 VAR_014751 rs12917 VAR_056129	53	L>F		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA5747980 rs773846744	53	L>P		No	ClinGen ExAC gnomAD
CA378911816 rs1211030036 CA378911815	54	G>R		No	ClinGen gnomAD
CA378911821 rs1248231973	55	G>C		No	ClinGen gnomAD
CA378911822 rs1248231973	55	G>S		No	ClinGen gnomAD
rs771707610 CA5747982	56	P>L		No	ClinGen ExAC TOPMed gnomAD
rs766218662 CA5747985	58	P>H		No	ClinGen ExAC gnomAD
CA216020348 rs766218662	58	P>L		No	ClinGen ExAC gnomAD
rs2308322 VAR_029112 CA5747984	58	P>S		No	ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD
rs747664825 CA5747988	60	M>I		No	ClinGen ExAC TOPMed gnomAD
CA5747987 rs376750435 CA378911848	60	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA216020350 rs1047413258	61	Q>R		No	ClinGen TOPMed gnomAD
CA5747977 rs769927494	61	Q>R		No	ClinGen ExAC gnomAD
rs1025932781 CA216020351	62	C>F		No	ClinGen TOPMed gnomAD
rs751605547 CA5747989	62	C>R		No	ClinGen ExAC TOPMed gnomAD
CA378911873 rs1321602870	63	T>I		No	ClinGen gnomAD
rs1437362833 CA378911877	64	A>G		No	ClinGen TOPMed gnomAD
CA5747990 rs200363326	64	A>P		No	ClinGen 1000Genomes ExAC gnomAD
CA378911874 rs200363326	64	A>S		No	ClinGen 1000Genomes ExAC gnomAD
CA5747991 rs200363326	64	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA5747992 VAR_020354 rs2282164	65	W>C		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
rs1279473464 CA378911878	65	W>R		No	ClinGen TOPMed gnomAD
rs369446171 CA5747993	67	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA5747994 rs780512062	68	A>T		No	ClinGen ExAC TOPMed gnomAD
rs749621475 CA5747995	69	Y>C		No	ClinGen ExAC
CA378911928 rs1301211456	72	Q>*		No	ClinGen gnomAD
rs755473287 CA5747996	72	Q>H		No	ClinGen ExAC gnomAD
CA5747998 rs137981522	74	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA378911939 rs137981522	74	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs143566017 CA5748000	75	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs746604806 CA5748001	75	A>V		No	ClinGen ExAC gnomAD
rs112373357 CA378911956	76	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA378911950 rs1473548584	76	I>V		No	ClinGen TOPMed gnomAD
CA5748003 rs776444084	77	E>K		No	ClinGen ExAC TOPMed gnomAD
CA378911965 rs1461054422	78	E>Q		No	ClinGen gnomAD
CA5748004 rs147505998	80	P>A		No	ClinGen ESP ExAC gnomAD
CA5748009 rs140112379	81	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs140112379 CA5748008	81	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5748010 rs761952141	82	P>L		No	ClinGen ExAC TOPMed gnomAD
VAR_014751 rs12917	84	L>F		No	UniProt dbSNP
rs199734815 CA5748013	85	H>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA5748016 rs754184302	86	H>Q		No	ClinGen ExAC gnomAD
rs766739852 CA5748015	86	H>R		No	ClinGen ExAC gnomAD
CA378912019 rs749585004	87	P>A		No	ClinGen ExAC TOPMed gnomAD
CA5748017 rs749585004	87	P>T		No	ClinGen ExAC TOPMed gnomAD
rs753200901 CA5748019	88	V>I		No	ClinGen ExAC TOPMed gnomAD
CA378912049 rs1256798399	91	Q>R		No	ClinGen TOPMed gnomAD
rs371761124 CA5748046	93	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs543916399 CA5748048	94	F>L		No	ClinGen 1000Genomes ExAC gnomAD
CA378710869 rs1484093476	94	F>Y		No	ClinGen TOPMed
CA378710878 rs1554884282	95	T>A		No	ClinGen Ensembl
CA5748049 rs768667991	96	R>K		No	ClinGen ExAC TOPMed gnomAD
CA378710896 rs1246394756	97	Q>*		No	ClinGen gnomAD
CA378710895 rs1246394756	97	Q>E		No	ClinGen gnomAD
CA5748051 rs747055327	99	L>S		No	ClinGen ExAC gnomAD
CA378710929 rs573158956 CA5748053	100	W>R		No	ClinGen ExAC TOPMed gnomAD
CA378710946 rs1299086540	101	K>R		No	ClinGen TOPMed
CA378710966 rs1228717899	103	L>P		No	ClinGen TOPMed
rs982730092 CA215497092	105	V>F		No	ClinGen gnomAD
CA378710985 rs1589979680	105	V>G		No	ClinGen Ensembl
rs759610626 CA5748055	107	K>Q		No	ClinGen ExAC gnomAD
rs1157452840 CA378711018	108	F>S		No	ClinGen gnomAD
rs775782259 CA5748057	109	G>R		No	ClinGen ExAC TOPMed gnomAD
rs2308321 VAR_014752 CA5748123 VAR_056130	112	I>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1324563035 CA378711079	114	Y>H		No	ClinGen TOPMed gnomAD
CA5748059 rs763354641	115	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA5748058 rs763354641	115	Q>E		No	ClinGen ExAC TOPMed gnomAD
rs763354641 CA215497101	115	Q>K		No	ClinGen ExAC TOPMed gnomAD
rs756743887 CA5748061	117	L>*		No	ClinGen ExAC gnomAD
CA378711131 rs374717890	118	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs938364024 CA215497113	118	A>P		No	ClinGen Ensembl
CA5748062 rs374717890	118	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs991529261 CA215497118	119	A>D		No	ClinGen TOPMed gnomAD
rs779780334 CA5748065	121	A>G		No	ClinGen ExAC gnomAD
CA5748064 rs755684450	121	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1487536499 CA378711171	123	N>S		No	ClinGen gnomAD
rs1487536499 CA378711170	123	N>T		No	ClinGen gnomAD
COSM1675663 CA5748066 rs749070988	124	P>L	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA378711219 rs1472497607	126	A>G		No	ClinGen TOPMed
rs748040489 CA5748069	127	A>G		No	ClinGen ExAC TOPMed gnomAD
CA5748068 rs778989637	127	A>T		No	ClinGen ExAC gnomAD
rs748040489 CA5748071 COSM1584868	127	A>V	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs148705827 CA5748073	128	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs148705827 CA5748074	128	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA5748075 rs3750824	128	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA378711260 rs1163744182	130	V>M		No	ClinGen gnomAD
CA5748076 rs763295892	131	G>E		No	ClinGen ExAC gnomAD
CA378711286 rs1458969796	132	G>R		No	ClinGen gnomAD
CA378711330 rs774714928	134	M>R		No	ClinGen ExAC gnomAD
rs774714928 CA5748078	134	M>T		No	ClinGen ExAC gnomAD
CA5748077 rs764496900	134	M>V		No	ClinGen ExAC gnomAD
CA5748079 rs762165032	135	R>K		No	ClinGen ExAC gnomAD
rs1276179130 CA378711402	137	N>S		No	ClinGen TOPMed
CA5748081 rs760473404	137	N>T		No	ClinGen ExAC
CA5748080 rs773189845	137	N>T		No	ClinGen ExAC
CA215497169 rs1000782674	138	P>S		No	ClinGen TOPMed
rs1564789228 CA378712924	139	V>I		No	ClinGen Ensembl
CA378712936 rs1337613297	140	P>L		No	ClinGen gnomAD
CA378712933 rs1345686595	140	P>T		No	ClinGen TOPMed
CA5748120 rs748430786	142	L>F		No	ClinGen ExAC TOPMed gnomAD
CA5748119 rs748430786	142	L>I		No	ClinGen ExAC TOPMed gnomAD
rs2308321 VAR_014752	143	I>V		No	UniProt dbSNP
CA5748124 rs776229993	144	P>L		No	ClinGen ExAC TOPMed gnomAD
CA5748125 rs776229993	144	P>R		No	ClinGen ExAC TOPMed gnomAD
rs528874121 CA5748127	148	V>M		No	ClinGen 1000Genomes ExAC gnomAD
CA378713001 rs1211320450	151	S>G		No	ClinGen gnomAD
CA215499774 rs371993381	151	S>R		No	ClinGen Ensembl
rs548839205 CA5748129	152	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs751313220 CA5748130	153	G>R		No	ClinGen ExAC gnomAD
CA5748133 rs753896761	155	V>M		No	ClinGen ExAC TOPMed gnomAD
CA378713030 rs1388471302	156	G>S		No	ClinGen TOPMed
CA378713043 rs1414794097	157	N>K		No	ClinGen gnomAD
CA5748136 rs2308318 VAR_014753	160	G>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1237068721 CA378713073	162	L>P		No	ClinGen TOPMed
CA215499786 rs747476742	163	A>V		No	ClinGen Ensembl
CA5748139 rs373120552	164	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA5748138 rs373120552	164	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA5748140 VAR_014754 rs2308320	166	E>D		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
rs1211599012 CA378713095	166	E>G		No	ClinGen TOPMed
rs777316575 CA5748141	167	W>*		No	ClinGen ExAC TOPMed gnomAD
CA378713122 rs1220134383	170	A>V		No	ClinGen TOPMed gnomAD
rs1267918510 CA378713126	171	H>P		No	ClinGen gnomAD
rs1036700765 CA215499796	172	E>A		No	ClinGen TOPMed gnomAD
rs1036700765 CA215499797	172	E>G		No	ClinGen TOPMed gnomAD
rs774873416 CA5748144	173	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1450516523 CA378713143	174	H>Y		No	ClinGen gnomAD
CA5748146 rs376927510	175	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA5748147 rs774150007	175	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5748145 rs376927510	175	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA378713152 rs61752719	176	L>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA378713153 rs61752719	176	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs755037750 CA5748151	177	G>E		No	ClinGen ExAC gnomAD
rs767414747 CA5748149 CA5748150	177	G>R		No	ClinGen ExAC TOPMed gnomAD
rs767414747 CA378713159	177	G>W		No	ClinGen ExAC TOPMed gnomAD
rs2308327 CA5748152 VAR_014755	178	K>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA5748153 rs752726386	180	G>S		No	ClinGen ExAC TOPMed gnomAD
CA378713184 rs200161468 CA5748156	181	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5748155 rs777904492	181	L>S		No	ClinGen ExAC gnomAD
CA5748157 rs757762502	186	G>A		No	ClinGen ExAC gnomAD
rs1188324184 CA378713226	188	A>V		No	ClinGen TOPMed
rs781760384 CA5748158	189	G>E		No	ClinGen ExAC gnomAD
CA378713232 rs1288043454	190	A>T		No	ClinGen TOPMed gnomAD
CA5748161 rs775022043	191	W>*		No	ClinGen ExAC gnomAD
rs200569730 CA5748160	191	W>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs768335853 CA5748164	195	A>T		No	ClinGen ExAC gnomAD
CA5748165 rs773919809	195	A>V		No	ClinGen ExAC TOPMed gnomAD
rs767359461 CA5748167	197	A>T		No	ClinGen ExAC TOPMed gnomAD
CA378713280 rs766247777	198	T>P		No	ClinGen ExAC gnomAD
CA5748170 rs766247777	198	T>S		No	ClinGen ExAC gnomAD
CA5748172 rs762983201	199	S>L		No	ClinGen ExAC TOPMed gnomAD
rs751884076 CA5748174 COSM3790598	200	G>C	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs757562187 CA5748175	202	P>L		No	ClinGen ExAC TOPMed gnomAD
CA215499838 rs919093471	203	P>S		No	ClinGen TOPMed
CA5748176 rs781633302	204	A>T		No	ClinGen ExAC gnomAD
rs750845258 CA5748177	205	G>D		No	ClinGen ExAC gnomAD
rs756598334 CA5748179	206	R>*		No	ClinGen ExAC TOPMed gnomAD
rs756598334 CA5748178	206	R>G		No	ClinGen ExAC TOPMed gnomAD
CA5748180 rs748805413	206	R>Q		No	ClinGen ExAC gnomAD

No associated diseases with P16455

3 regional properties for P16455

Type	Name	Position	InterPro Accession
active_site	Methylated-DNA-[protein]-cysteine S-methyltransferase, active site	143 - 149	IPR001497
domain	Methylguanine DNA methyltransferase, ribonuclease-like domain	6 - 90	IPR008332
domain	Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding	94 - 173	IPR014048

Functions

		Description
EC Number	2.1.1.63	Methyltransferases
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name	Definition
calcium ion binding	Binding to a calcium ion (Ca2+).
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-methyltransferase activity	Catalysis of the transfer of a methyl group to a DNA molecule.
methylated-DNA-[protein]-cysteine S-methyltransferase activity	Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.
methyltransferase activity	Catalysis of the transfer of a methyl group to an acceptor molecule.

14 GO annotations of biological process

Name	Definition
cellular response to ionizing radiation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.
cellular response to organic cyclic compound	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
cellular response to oxidative stress	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
DNA dealkylation involved in DNA repair	The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).
DNA ligation	The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase.
DNA repair	The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
mammary gland epithelial cell differentiation	The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
positive regulation of double-strand break repair	Any process that activates or increases the frequency, rate or extent of double-strand break repair.
regulation of cysteine-type endopeptidase activity involved in apoptotic process	Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis.
response to ethanol	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
response to folic acid	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus.
response to toxic substance	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
response to xenobiotic stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P24528	Mgmt	Methylated-DNA--protein-cysteine methyltransferase	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MDKDCEMKRT	TLDSPLGKLE	LSGCEQGLHE	IKLLGKGTSA	ADAVEVPAPA	AVLGGPEPLM
70	80	90	100	110	120
QCTAWLNAYF	HQPEAIEEFP	VPALHHPVFQ	QESFTRQVLW	KLLKVVKFGE	VISYQQLAAL
130	140	150	160	170	180
AGNPKAARAV	GGAMRGNPVP	ILIPCHRVVC	SSGAVGNYSG	GLAVKEWLLA	HEGHRLGKPG
190	200
LGGSSGLAGA	WLKGAGATSG	SPPAGRN