P16311
Gene name |
DERF1 |
Protein name |
Peptidase 1 |
Names |
|
Species |
Dermatophagoides farinae (American house dust mite) |
KEGG Pathway |
|
EC number |
3.4.22.65: Cysteine endopeptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P16311
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5VPK | X-ray | 200 A | A/B/C | 99-321 | PDB |
| 5VPL | X-ray | 190 A | A | 99-321 | PDB |
| AF-P16311-F1 | Predicted | AlphaFoldDB |
No variants for P16311
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P16311 | |||||
No associated diseases with P16311
6 regional properties for P16311
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| active_site | Cysteine peptidase, cysteine active site | 127 - 138 | IPR000169 |
| domain | Peptidase C1A, papain C-terminal | 109 - 320 | IPR000668 |
| domain | Cathepsin propeptide inhibitor domain (I29) | 26 - 75 | IPR013201 |
| active_site | Cysteine peptidase, histidine active site | 267 - 277 | IPR025660 |
| active_site | Cysteine peptidase, asparagine active site | 284 - 303 | IPR025661 |
| domain | Papain-like cysteine endopeptidase | 110 - 319 | IPR039417 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.22.65 | Cysteine endopeptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKFVLAIASL | LVLSTVYARP | ASIKTFEEFK | KAFNKNYATV | EEEEVARKNF | LESLKYVEAN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KGAINHLSDL | SLDEFKNRYL | MSAEAFEQLK | TQFDLNAETS | ACRINSVNVP | SELDLRSLRT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VTPIRMQGGC | GSCWAFSGVA | ATESAYLAYR | NTSLDLSEQE | LVDCASQHGC | HGDTIPRGIE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YIQQNGVVEE | RSYPYVAREQ | RCRRPNSQHY | GISNYCQIYP | PDVKQIREAL | TQTHTAIAVI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IGIKDLRAFQ | HYDGRTIIQH | DNGYQPNYHA | VNIVGYGSTQ | GDDYWIVRNS | WDTTWGDSGY |
| 310 | 320 | ||||
| GYFQAGNNLM | MIEQYPYVVI | M |