P16289

PR
Gene name
L
Protein name
Large structural protein
Names
Protein L, Replicase, Transcriptase
Species
Rabies virus (strain SAD B19) (RABV)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

452-522 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P16289

Entry ID Method Resolution Chain Position Source
6UEB EM 330 A A 1-2127 PDB

16 variants for P16289

Variant ID(s) Position Change Description Diseaes Association Provenance
26 I>T strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2 [UniProt] No
365 F>Y strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2 [UniProt] No
391 L>I strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2 [UniProt] No
394 M>V strain: SRV9, Isolate SAD1-3670 var 1, Isolate SAD1-3670 var 2, Isolate SAD Bern, Isolate SAD Bern original var 1, Isolate SAD Bern original var 2, Isolate SAD Bern original var 3, Isolate SAD Bern original var 4, Isolate SAD Bern original var 5, Isolate SAD P5/88, Isolate SAD VA1 and Isolate SAG 2 [UniProt] No
524 R>K strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2 [UniProt] No
901 I>V strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2 [UniProt] No
933 Q>H strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2 [UniProt] No
1018 I>T strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2 [UniProt] No
1100 L>Q strain: SRV9 [UniProt] No
1212 A>T strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2 [UniProt] No
1450 V>I strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2 [UniProt] No
1516 I>V strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2 [UniProt] No
1541 S>T strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2 [UniProt] No
1761 L>F strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2 [UniProt] No
1990 S>L strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2 [UniProt] No
2097 R>G strain: Isolate SAD1-3670 var 1 and Isolate SAD1-3670 var 2 [UniProt] No

No associated diseases with P16289

5 regional properties for P16289

Type Name Position InterPro Accession
domain Mononegavirales RNA-directed RNA polymerase catalytic domain 35 - 1083 IPR014023
domain Mononegavirus L protein 2-O-ribose methyltransferase 1674 - 1871 IPR025786
domain Mononegavirales mRNA-capping domain V 1093 - 1326 IPR026890
domain RNA-directed RNA polymerase L methyltransferase domain, rhabdovirus 1361 - 2051 IPR039530
domain RNA-directed RNA polymerase L, C-terminal 1189 - 2093 IPR039736

Functions

Description
EC Number
Subcellular Localization
  • Virion
  • Host cytoplasm
  • L and P are packaged asymmetrically towards the blunt end of the virus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
host cell cytoplasm The cytoplasm of a host cell.
virion component Any constituent part of a virion, a complete fully infectious extracellular virus particle.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
mRNA (guanine-N7-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

1 GO annotations of biological process

Name Definition
negative stranded viral RNA replication A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLDPGEVYDD PIDPIELEAE PRGTPIVPNI LRNSDYNLNS PLIEDPARLM LEWLKTGNRP
70 80 90 100 110 120
YRMTLTDNCS RSFRVLKDYF KKVDLGSLKV GGMAAQSMIS LWLYGAHSES NRSRRCITDL
130 140 150 160 170 180
AHFYSKSSPI EKLLNLTLGN RGLRIPPEGV LSCLERVDYD NAFGRYLANT YSSYLFFHVI
190 200 210 220 230 240
TLYMNALDWD EEKTILALWK DLTSVDIGKD LVKFKDQIWG LLIVTKDFVY SQSSNCLFDR
250 260 270 280 290 300
NYTLMLKDLF LSRFNSLMVL LSPPEPRYSD DLISQLCQLY IAGDQVLSMC GNSGYEVIKI
310 320 330 340 350 360
LEPYVVNSLV QRAEKFRPLI HSLGDFPVFI KDKVSQLEET FGPCARRFFR ALDQFDNIHD
370 380 390 400 410 420
LVFVFGCYRH WGHPYIDYRK GLSKLYDQVH LKKMIDKSYQ ECLASDLARR ILRWGFDKYS
430 440 450 460 470 480
KWYLDSRFLA RDHPLTPYIK TQTWPPKHIV DLVGDTWHKL PITQIFEIPE SMDPSEILDD
490 500 510 520 530 540
KSHSFTRTRL ASWLSENRGG PVPSEKVIIT ALSKPPVNPR EFLRSIDLGG LPDEDLIIGL
550 560 570 580 590 600
KPKERELKIE GRFFALMSWN LRLYFVITEK LLANYILPLF DALTMTDNLN KVFKKLIDRV
610 620 630 640 650 660
TGQGLLDYSR VTYAFHLDYE KWNNHQRLES TEDVFSVLDQ VFGLKRVFSR THEFFQKAWI
670 680 690 700 710 720
YYSDRSDLIG LREDQIYCLD ASNGPTCWNG QDGGLEGLRQ KGWSLVSLLM IDRESQIRNT
730 740 750 760 770 780
RTKILAQGDN QVLCPTYMLS PGLSQEGLLY ELERISRNAL SIYRAVEEGA SKLGLIIKKE
790 800 810 820 830 840
ETMCSYDFLI YGKTPLFRGN ILVPESKRWA RVSCVSNDQI VNLANIMSTV STNALTVAQH
850 860 870 880 890 900
SQSLIKPMRD FLLMSVQAVF HYLLFSPILK GRVYKILSAE GESFLLAMSR IIYLDPSLGG
910 920 930 940 950 960
ISGMSLGRFH IRQFSDPVSE GLSFWREIWL SSQESWIHAL CQEAGNPDLG ERTLESFTRL
970 980 990 1000 1010 1020
LEDPTTLNIR GGASPTILLK DAIRKALYDE VDKVENSEFR EAILLSKTHR DNFILFLISV
1030 1040 1050 1060 1070 1080
EPLFPRFLSE LFSSSFLGIP ESIIGLIQNS RTIRRQFRKS LSKTLEESFY NSEIHGISRM
1090 1100 1110 1120 1130 1140
TQTPQRVGGV WPCSSERADL LREISWGRKV VGTTVPHPSE MLGLLPKSSI SCTCGATGGG
1150 1160 1170 1180 1190 1200
NPRVSVSVLP SFDQSFFSRG PLKGYLGSST SMSTQLFHAW EKVTNVHVVK RALSLKESIN
1210 1220 1230 1240 1250 1260
WFITRDSNLA QALIRNIMSL TGPDFPLEEA PVFKRTGSAL HRFKSARYSE GGYSSVCPNL
1270 1280 1290 1300 1310 1320
LSHISVSTDT MSDLTQDGKN YDFMFQPLML YAQTWTSELV QRDTRLRDST FHWHLRCNRC
1330 1340 1350 1360 1370 1380
VRPIDDVTLE TSQIFEFPDV SKRISRMVSG AVPHFQRLPD IRLRPGDFES LSGREKSHHI
1390 1400 1410 1420 1430 1440
GSAQGLLYSI LVAIHDSGYN DGTIFPVNIY GKVSPRDYLR GLARGVLIGS SICFLTRMTN
1450 1460 1470 1480 1490 1500
ININRPLELV SGVISYILLR LDNHPSLYIM LREPSLRGEI FSIPQKIPAA YPTTMKEGNR
1510 1520 1530 1540 1550 1560
SILCYLQHVL RYEREIITAS PENDWLWIFS DFRSAKMTYL SLITYQSHLL LQRVERNLSK
1570 1580 1590 1600 1610 1620
SMRDNLRQLS SLMRQVLGGH GEDTLESDDN IQRLLKDSLR RTRWVDQEVR HAARTMTGDY
1630 1640 1650 1660 1670 1680
SPNKKVSRKV GCSEWVCSAQ QVAVSTSANP APVSELDIRA LSKRFQNPLI SGLRVVQWAT
1690 1700 1710 1720 1730 1740
GAHYKLKPIL DDLNVFPSLC LVVGDGSGGI SRAVLNMFPD AKLVFNSLLE VNDLMASGTH
1750 1760 1770 1780 1790 1800
PLPPSAIMRG GNDIVSRVID LDSIWEKPSD LRNLATWKYF QSVQKQVNMS YDLIICDAEV
1810 1820 1830 1840 1850 1860
TDIASINRIT LLMSDFALSI DGPLYLVFKT YGTMLVNPNY KAIQHLSRAF PSVTGFITQV
1870 1880 1890 1900 1910 1920
TSSFSSELYL RFSKRGKFFR DAEYLTSSTL REMSLVLFNC SSPKSEMQRA RSLNYQDLVR
1930 1940 1950 1960 1970 1980
GFPEEIISNP YNEMIITLID SDVESFLVHK MVDDLELQRG TLSKVAIIIA IMIVFSNRVF
1990 2000 2010 2020 2030 2040
NVSKPLTDPS FYPPSDPKIL RHFNICCSTM MYLSTALGDV PSFARLHDLY NRPITYYFRK
2050 2060 2070 2080 2090 2100
QVIRGNVYLS WSWSNDTSVF KRVACNSSLS LSSHWIRLIY KIVKTTRLVG SIKDLSREVE
2110 2120
RHLHRYNRWI TLEDIRSRSS LLDYSCL