P16263

PR
Gene name
odhB (citM, BSU19360)
Protein name
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex
Names
2-oxoglutarate dehydrogenase complex component E2, OGDC-E2, Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex
Species
Bacillus subtilis (strain 168)
KEGG Pathway
bsu:BSU19360
EC number
2.3.1.61: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

49-221 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P16263

Entry ID Method Resolution Chain Position Source
AF-P16263-F1 Predicted AlphaFoldDB

No variants for P16263

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P16263

No associated diseases with P16263

4 regional properties for P16263

Type Name Position InterPro Accession
domain Biotin/lipoyl attachment 1 - 76 IPR000089
domain 2-oxoacid dehydrogenase acyltransferase, catalytic domain 187 - 415 IPR001078
binding_site 2-oxo acid dehydrogenase, lipoyl-binding site 26 - 55 IPR003016
domain Peripheral subunit-binding domain 123 - 160 IPR004167

Functions

Description
EC Number 2.3.1.61 Transferring groups other than amino-acyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
oxoglutarate dehydrogenase complex A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).

1 GO annotations of molecular function

Name Definition
dihydrolipoyllysine-residue succinyltransferase activity Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide.

2 GO annotations of biological process

Name Definition
L-lysine catabolic process to acetyl-CoA via saccharopine The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate saccharopine.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAEIKVPELA ESISEGTIAQ WLKQPGDYVE QGEYLLELET DKVNVELTAE ESGVLQEVLK
70 80 90 100 110 120
DSGDTVQVGE IIGTISEGAG ESSAPAPTEK TESKESVKEE KQAEPAAQEV SEEAQSEAKS
130 140 150 160 170 180
RTIASPSARK LAREKGIDLS QVPTGDPLGR VRKQDVEAYE KPASKPAPQQ KQQPQAQKAQ
190 200 210 220 230 240
QSFDKPVEVQ KMSRRRQTIA KRLVEVQQTS AMLTTFNEVD MTAVMNLRKR RKDQFFEQNE
250 260 270 280 290 300
VKLGFMSFFT KAVVAALKKY PLLNAEIQGD ELIVKKFYDI GIAVAADEGL VVPVVRDADR
310 320 330 340 350 360
LTFAGIEKEI GELAKKARNN KLTLSELQGG SFTITNGGTF GSLMSTPILN SPQVGILGMH
370 380 390 400 410
KIQLRPVAID EERFENRPMM YIALSYDHRI VDGKEAVGFL VTIKNLLEDP EQLLLEG